摘要
目的:观察选择性M-受体拮抗剂长托宁用于腹部外科术前准备的临床效果。方法:选取腹部外科择期手术69例,随机分为3组(每组23例):对照组(Ⅰ组),不应用术前药;阿托品组(Ⅱ组)和长托宁组(Ⅲ组),分别于麻醉诱导前30min肌肉注射阿托品或长托宁0.01mg/kg,记录用药后诱导前患者口腔干燥程度,气管插管后5min至术毕拔管时气道分泌物量及心率。结果:用药后Ⅱ组患者的心率明显高于Ⅲ组和Ⅰ组,差异有统计学意义(P<0.05)。诱导前至气管插管后2h,Ⅱ组和Ⅲ组患者的气道分泌物明显少于Ⅰ组(P<0.05)。术毕拔管时,Ⅱ组患者的气道分泌物则多于Ⅲ组(P<0.05)。结论:选择性新型M-受体拮抗剂长托宁用于腹部外科手术术前用药临床效果优于阿托品。
Objective： To investigate the effectiveness of administration of Penehyclidine Hydrochloride which is selective antagonist on receptor-M as Premedication in abdominal surgery. Method s： There were 69 patients, scheduled for elective abdominalsurgical operation were randomly divided into three groups （n=23）： control group （ Ⅰ group）without administration; atropine group （ Ⅱ group）and penehyclidine hydrochloride group （Ⅲ group）were injected with 0.01 mg/kg atropine or penehyclidine hydrochloride muscularly 30 rain before anesthesia induction. The degree of xerostomia after administration and before induction, the volume of secretion in airway and the heart rate were recorded from tracheal cannula insertion 5 min later to extubation after operation. Results： After administration, heart rate increased significantly in Ⅱ group than that in Ⅰ group and Ⅲ group（P〈0.05）. The volume of secretion in airway in Ⅱ group and Ⅲ group was significantly less than that in I group from before induction to after tracheal cannula insertion 2 h （P〈0.05）. However, after operation and extubation, the volume of secretion in airway in Ⅱ group was much more than that in Ⅲ group （P〈0.05）. Conclusion： Administration of Penehyclidine Hydrochloride which is selective antagonist on receptor-M as Premedication is more effective and better than Atropine in abdominal surgery.
出处
《天津医科大学学报》
2005年第4期621-623,共3页
Journal of Tianjin Medical University
关键词
术前药
长托宁
腹部外科
阿托品
Premedication
Penehyclidine Hydrochloride
Abdominal surgery
Atropine
