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体外混合淋巴细胞培养对心脏移植急性排斥反应的监测作用 被引量：3

Mixed lymphocyte culture in vitro in monitoring acute rejection of cardiac transplantation
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摘要 目的:研究体外单向混合淋巴细胞培养作为无创的心脏移植排斥反应监测方法的可行性.方法:通过改良的单向混合淋巴细胞培养与心肌内膜活检(EMB)相对照,测定淋巴细胞活性与心肌活检病理等级的相关性.结果:改良的体外单向混合淋巴细胞培养方法与心肌内膜活检病理等级有很好的相似性.结论:改良的体外单向混合淋巴细胞培养方法可作为无创监测心脏移植排斥反应的有效手段之一. AIM： To study the use of mixed lymphocyte culture in non-invasive surveillance of acute rejection after cardiac transplantation. METHODS： We compared the results of modified mixed lymphocytes culture and endomyocardial biopsy （EMB） and analyzed the relationship of the activity of peripheral lymphocytes and myocardial biopsy grades. RESULTS： Modified mixed lymphocyte culture had a very close correlation with the incidence of rejection reaction, which was valuable for the early diagnose of rejection. CONCLUSION： Modified mixed lymphocyte culture can be used as a non-invasive method to efficaciously monitor acute rejection.
作者 马涛 胡军 蔡振杰 李彤 王晓武 程亮
机构地区 第四军医大学西京医院心血管外科
出处 《第四军医大学学报》 北大核心 2006年第1期27-29,共3页 Journal of the Fourth Military Medical University
关键词 心脏移植 移植物排斥 混合淋巴细胞培养 监测 heart transplantation graft rejection mixed lymphocyte culture monitoring
分类号 R654.2 [医药卫生—外科学]
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参考文献9

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同被引文献24

  • 1王亭忠,席雨涛,吴格如,马爱群.大鼠成体心肌细胞的分离和培养[J].第四军医大学学报,2005,26(17):1544-1546. 被引量：15
  • 2李荣,郭晖,王大卫,谢林,曾梦华,王树森,王璐,陈实.建立同种大鼠心脏移植超急性排斥反应动物模型[J].中华器官移植杂志,2006,27(4):235-236. 被引量：2
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  • 8Wang H, Rollins SA, Gao Z, et al. Complement inhibition with an anti-C5 monoclonal antibody prevents hyperacute rejection in a xenograft heart transplantation model. Trans plantation, 1999, 68(11) : 1643-1651.
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第四军医大学学报
2006年 第1期

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