摘要
2,3-二氨基-6-甲氧基吡啶和乙氧基荒酸钾经闭环得到5-甲氧基-1H-咪唑并[4,5-b]吡啶-2-硫醇,再与2-氯甲基-3,5-二甲基-4-甲氧基吡啶缩合后氧化得到抗溃疡药泰妥拉唑,总收率48%。
Tenatoprazole was synthesized from 2,3-diamino-6-methoxypyridine by cyclization with potassium xanthogenate to give 5-methoxy- 1H-imidazo [4,5-b] pyridine-2-thiol which subjected to condensation with 2-chloromethyl- 3,5-dimethyl-4-methoxypyridine followed by oxidation with an overall yield of 48 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第1期3-4,共2页
Chinese Journal of Pharmaceuticals
