摘要
目的探讨急性脑梗死时患者体内脂质过氧化及纤溶状况,指导临床治疗。方法采用单克隆酶联免疫吸附(ELISA)双抗体夹心法测定了56例脑梗死患者的氧化修饰低密度脂蛋白(ox-LDL)和D-二聚体(D-D im er)的水平。结果急性脑梗死者ox-LDL为(0.48±0.23)mg/L,较<60岁正常对照组(0.35±0.12)mg/L和≥60岁正常对照组(0.39±0.17)mg/L明显升高(P<0.01),≥60岁正常对照组较<60岁正常对照组明显高(P<0.05);D-D im er急性脑梗死者(1.63±0.98)mg/L,较<60岁正常对照组(0.27±0.16)mg/L和≥60岁正常对照组者(0.46±0.21)mg/L呈显著性升高(P<0.01);≥60岁正常对照组与<60岁正常对照组相比较也有显著性差异(P<0.01)。结论脑梗死及健康老年人均存在脂质过氧化和纤溶活性的增强,适当予以抗氧化及溶栓治疗是降低老年人发病率及脑梗死病人死亡率的一项有效措施。
Objective To investigate the condition of lipid hyperoxidation and fibrinolysis in 56 acute cerebral infarction patients in order to instruct the clinical therapy. Methods The concentrations of oxidatively modified low-density lipoprotein （ox-LDL） and D-dimer were measured by a sandwich-ELISA assay with monoclonal antibody （McAb）, Results The avemge concentration of ox-LDL in patients with acute cerebral infarction was 0.48 ＋ 0.23 mg/L, while in control group it was 0.35 ＋ 0.12 mg/L, with a significant discrepance between these two groups （ P 〈 0. 01 ）. The ox-LDL level in healthy older people （0.39 ＋ 0.17 mg/L） was also higher than that in control group （ P 〈 0.01）. The investigation into the patients with acute cerebral infarction showed that the D-dimer level （0.63 ＋ 0.98 mg/L） was higher than that of the control group （0.27 ± 0.16 mg/L） and than that of the healthy older people （ 0.46 ＋ 0.21 mg/L） （ P 〈 0.01 ） , and the difference between the healthy older people and the control group was alsc significant （ P 〈 0.01 ）. Conclusion It is concluded that there are increases of lipid hyperoxidation and fibrinolysis in the cerebra] infarction patients and healthy older people. The results suggest that giving antioxldatlon and thrombolysis therapy is good to decreasing the incidence rate of older people and the death rate of cerebral infarction patients.
出处
《临床军医杂志》
CAS
2005年第6期685-686,共2页
Clinical Journal of Medical Officers
