摘要
肺癌骨转移常严重影响患者的生活质量及生存期,因此须尽早诊断和恰当处理。骨转移的临床诊断方法包括X线平片、CT、MRI、ECT、PET等,其敏感性和特异性各有不同;新近的基因芯片技术对肿瘤微转移灶进行早期诊断,对肿瘤细胞的基因分析还有助于更好了解原发肿瘤的生物学特性及寻找有效措施早期清除微转移灶。治疗包括局部和全身治疗。外科手术主要用于预防或治疗局部压迫及骨折,放疗则为止痛的有效措施。二磷酸盐类、特别是第三代二磷酸盐类的开发,为中晚期肺癌骨转移患者的姑息治疗提供了一种方便有效的方法。此外,积极的支持对症治疗同样十分重要。
Bone metastases in advanced lung cancer patients are common and affect the life quality seriously. So early diagnosis and appropriate treatments are important. The methods of diagnosis include X-ray, CT, MRI, ECT and PET, which are different in sensitivity and specificity. The gene microarray technique is another advance for detecting microlnetastasis. The gene analysis also can help understanding the biological characteristics of the primary tumor. The treatment of bone metastases in lung cancer is various, including systemic and local therapeutic means. Surgery is often used to prevent or treat the compressions and bone fractures. Radiotherapy is one of the most effective methods of pain relief. Diphosphonate provides a new convenient and effective way of alleviative treatment. In addition, supportive and sylnptolnatic treatments should be keep in mind.
出处
《中国癌症杂志》
CAS
CSCD
2005年第6期583-587,共5页
China Oncology
关键词
肺癌
骨转移瘤
诊断
治疗
lung cancer
osseous metastasis
diagnose
therapy
