摘要
目的探讨凋亡抑制基因Survivin在膀胱移行细胞癌中的表达及与bc l-2蛋白表达的相关性。方法应用免疫组织链酶卵白素-过氧化物酶复合物(SP)方法,检测40例膀胱移行细胞癌组织标本中Survivin、bc l-2蛋白的表达,并与15例正常膀胱粘膜移行细胞进行对照研究。结果40例膀胱移行细胞癌中,Survivin蛋白的阳性表达率为58.14%,而正常膀胱粘膜组织中未见Survivin蛋白阳性表达(P<0.01)。Survivin蛋白表达与膀胱移行细胞癌的WHO肿瘤分级有相关性。根据Spearm an相关分析表明Survivin与bc l-2蛋白表达正相关(P<0.01)。结论Survivin基因可通过抑制膀胱移行细胞癌细胞凋亡,对膀胱移行细胞癌的发生发展起重要作用。Survivin基因的表达与膀胱癌组织中bc l-2蛋白的异常表达密切相关。
Objective To investigate the expressions of survivin and bcl -2 and their relationships in transitional cell carcinoma of the bladder. Methods The expressions of survivin and bcl - 2 in 40 eases of transitional cell carcinoma of the bladder were detected with streptavidin - biotin peroxidase（SP） method, with 15 eases of normal bladder specimens as controls, Results Survivin was expressed in 25 of 40 （58. 149% ） eases of bladder carcinoma tissues, and normal bladder specimens did not express survivin （ P 〈 0. 01 ）. The expression of bcl -2 was positively correlated with survivin expression （ P 〈 0.01 ）. Conclusion Survivin inhibits the apoptosis of the tumor cells and plays an important role in the carcinogenesis and development of the transitional cell carcinoma of the bladder. The expression of survivin is closely associated with the abnormal expression of bcl - 2.
出处
《中国医师杂志》
CAS
2005年第12期1631-1632,共2页
Journal of Chinese Physician
