摘要
采用家兔失血性休克／再灌注模型（Ｓ／Ｒ），观察损伤后血浆中一氧化氮（ＮＯ）终代谢产物的改变及磷脂酶Ａ＿２阻断剂氯喹及其同类合成药磷酸萘酚喹、抗氧化剂黄芪酮治疗对其的影响。结果表明Ｓ／Ｒ后２４ｈ内血浆含量逐渐下降同血ｐＨ值及二氧化碳结合力ＴＣＯ＿２下降有正相关；应用磷脂酶Ａ＿２阻断剂和抗氧化剂可在一定程度上阻断的减少，且对维持体内酸碱平衡有一定作用。
The changes of plasma nitric oxide metabolites- were observed after hemorrhagic shock/reperfu-sion injury (S/R)in rabbits.The results showed that the level was positively correlated with the de-crease of TCO_2 and pH values after S/R 24 h,and phosphilipase A_2 inhibitor chloroquine, ME8101 as well asantioxidant(TFA)could be used to block the decrease of nitric oxide and maintain the acid-base balance in vi-vo.
出处
《军医进修学院学报》
CAS
1996年第2期84-87,共4页
Academic Journal of Pla Postgraduate Medical School
基金
"八五"军队医药卫生科研基金
关键词
出血性休克
再灌注损伤
一氧化氮
磷脂酶A类
hemorrhagic shock
reperfusion
nitric oxide
phospholipase A_2
antioxidants
acidosis
