摘要
目的探讨免疫营养剂谷氨酰胺(Glutamine,Gln)对梗阻性黄疸大鼠可溶性白细胞介素2受体(sIL-2R)的影响。方法90只大鼠随机分成对照组(C组)、梗阻性黄疸组(J组)和谷氨酰胺干预组(G组)各30只,于术后5周抽尽腔静脉血测定血清sIL-2R。结果J组与G组sIL-2R水平较C组明显升高(P<0·01),G组sIL-2R水平较J组明显降低,差异显著(P<0·01)。结论谷氨酰胺能够降低梗阻性黄疸大鼠sIL-2R水平,改善机体免疫状态。
Objective To investigate the effect of glutamine（Gin） on soluble interleukin 2 receptor（sIL-2R） of obstructive jaundice（OJ） rats. Methods 90 rats were divided into contrast group（C group）, obstructive jaundice group（J group） and Gin treatment group（G group）. All the venacavalblood samples were obtained 5 weeks after operation, and then detect the serum sIL-2R level. Resuits The serum sIL-2R level of J and G group was obviously higher than that of C group（ P 〈 0.01 ）, and the serum sIL-2R level of G group lower than the J group. And the difference between Jgroup and G group was significant（ P 〈 0.01 ）. Conclusion The administration of glutamine can lower the serum slL-2R level of OJ rats, thus can improve the immune status.
出处
《中国实验诊断学》
2005年第6期934-935,共2页
Chinese Journal of Laboratory Diagnosis
基金
吉林省科技厅资助项目(20030542-2)
关键词
梗阻性黄疸
谷氨酰胺
白细胞介素2受体
obstructive jaundice
glutamine
soluble interleukin 2 receptor
