摘要
用离体小血管收缩功能实验法比较了Ｗｉｓｔａｒ大鼠基底动脉（ＢＡ）和肾动脉（ＲＡ）β和α（α_１和α_２）肾上腺素受体分布和功能的差异。结果表明：（１）由β受体介导的非内皮依赖性舒张反应在ＢＡ明显强于ＲＡ，提示ＢＡ的β受体分布多于ＲＡ。（２）大多数ＢＡ对α_１激动剂无反应，仅个别ＢＡ对α_１激动剂显示一种低亲和力、低效能的收缩反应，这与ＲＡ明显不同。提示大多数ＢＡ无α_１受体分布，仅个别ＢＡ有α１受体分布，但其亚型可能不同于ＲＡ上的α_１受体亚型。（３）无论是保留内皮还是去除内皮，ＢＡ对α_２受体激动剂ＢＨＴ９２０（１０￣（－５）ｍｏｌ／Ｌ）均无反应，而在ＲＡ保留内皮对ＢＨＴ９２０（１０￣（－５）ｍｏｌ／Ｌ）呈舒张反应，去内皮后则呈收缩反应。提示在大鼠ＢＡα２受体分布极少，而在ＲＡ则有α_２受体分布，且内皮之α_２受体介导内皮依赖性舒张反应，平滑肌之α_２受体介导内皮非依赖性收缩反应。
A comparative study was made on the distribution of α-and β-adrenoceptors between rat basilar(BA) and renal arteries(RA).The results showed that(1) the endothelium-independent relaxation due to β-agonism was more significant in BA than that in RA;(2)there was no α1-adrenoceptor-mediated vasoconstriction in most of the BA,only a small part of BA showed constriction in response to α1-agonism,but with low affinity and efficacy and a desensitization tendency;(3)no response to α2-agonist BHT 920(10-5 mol/L)in BA was shown,either in the presence or absence of endothelium,But in RA there was relaxation in the presence of endothelium and constriction in its absence,The above results suggest that there is a scarce distribution of α1-and α2-adrenoceptors,but an abundant distribution of β-adrenoceptor in basilar artery compared with that in renal artery. The α1subtype in BA is different from the α1-subtype in RA,and the α2-receptor which mediates direct smooth muscle constriction and endothelium-dependent relaxation is highly heterogeneous between basilar and renal arterles.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1996年第4期279-283,共5页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金
关键词
肾上腺素
受体
内皮
基底动脉
肾动脉
s adrenoceptors
endothelium
vascular smooth muscle
basilar arteryp
renal artery
