摘要
目的探讨血清一氧化氮(NO)和C反应蛋白(CRP)在梅毒患者及其临床分期中的表达。方法采用硝酸还原酶法和免疫比浊法,检测并比较86例梅毒患者和80例健康正常人的NO和CRP含量,同时根椐临床分期分别比较Ⅰ期(n=37)、Ⅱ期(n=29)、Ⅲ期(n=20)梅毒患者的NO和CRP含量。结果梅毒患者血清中CRP和NO浓度明显高于正常对照组(P均<0.01)。随着梅毒临床分期的增高CRP水平明显下降(P<0.01),而NO水平随分期的增高而升高(P<0.01)。结论CRP和NO水平是诊断梅毒螺旋体感染敏感的生化指标,并有助于临床的分期,也对判断治疗的效果及预后起着重要的作用。
Objective To study the expression of Nitiric oxide（NO） and c reactive protein（CRP） in the clinical stages of the syphilis patients. Methods The level of NO and CRP in 86 patients and 80 normal people were detected and compared. Automatic biochemistry analyzer was adopted. At the same time, the patients were divided into three groups by the clinical stages. And their level of NO and CRP were compared. Results The CRP concentration was 35.21±4.50 mg/L in the sera of the syphilis patients, and the level of NO was 158.81 ±30. 10 /zmol/L, both of which were significantly higher than the control group（ P〈0.01）. The level of NO and CRP decreased as the patient＇s clinical stages increased （ P 〈0.01）. Conclusion The detection of NO and CRP is a sensitive norm for clinical diagnosis of syphilis in biochemistry tests, which is helpful for the clinical stages. It plays an important role in the evaluation of syphilis effect of treatment and prognosis.
出处
《右江医学》
2005年第6期575-577,共3页
Chinese Youjiang Medical Journal
关键词
梅毒螺旋体
临床分期
一氧化氮
C反应蛋白
treponema pallidum
clinical stages
nitiric oxide
c reactive protein
