摘要
目的:考察电解质对全肠外营养液稳定性的影响.方法:对4组加入不同电解质的全肠外营养液,于配制后0h及20℃～22℃下贮存4、8、12、16、24h后分别取样测定pH值和溶液微粒数变化,并肉眼观察其外观变化.结果:4组pH值在24h内均未发生明显变化;≥5μm的微粒数除加入1、2价电解质组(第4组)一开始就急速增至峰值外,其余均随放置时间延长而增加;加入2价电解质组(第3组)和加入1、2价电解质组(第4组)配制后6h即出现分层现象,加入1价电解质组(第2组)12h发生乳凝反应,而未加入电解质组(第1组)24h内无沉淀和分层现象.结论:电解质对全肠外营养液的稳定性有一定影响,在配制时应注意电解质用量,配制后应尽快输注,放置不宜超过24h.
OBJECTIVE： To investigate the effect of electrolytes on the stability of the total parenteral nutrient（TPN） solutions.METHODS： The pH values and number changes of solution microparticles of 4 groups of TPN sample solutions that of different electrolytes were determined at Oh after preparation and 4 hours, 8hours, 12hours, 16hours and 24hours, respectively after storage under room temperature（20℃- 22℃ ） . And the appearances of which were observed under naked eyes. RESULTS： No changes were noted as for the pH of 4 groups of solutions within 24h .For the numbers of microparticles（≥5μm）, those in Group 4（to which group valence 1 and valence 2 electrolytes were added） showed a rapid increase to peak value from the very start;while those of the other groups increased with the extension of storage time .Stratification appeared in Group 3（to which group, valence 2 electrolytes had been added） and Group 4（to which group, valence 1 and valence 2 electrolytes were added） 6 hours after preparation.Curdling reaction was noted in Group 2（to which group, valence 1 electrolytes had been added） at 12th hour. Neither sediments nor stratification appeared in Group 1（no electrolytes were added to which group）. CONCLUSION ：Electrolytes have certain influences on the stability of the TPN solutions.Care should be taken to the dosage of which at preparation .Furthermore, once prepared, the solution should be infused as soon as possible and the storage of which should not beyond 24h.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第23期1824-1826,共3页
China Pharmacy
关键词
全肠外营养液
电解质
稳定性
Total parenteral nutrient solutions
Electrolytes
Stability
