摘要
研究了在0.2 mol/L Na2SO4水溶液中乙酰二茂铁(Acetylferrocene, AFc)在玻碳电极上催化氧化N-乙酰-L-半胱氨酸(N-Acetyl-L-Cysteine, NAC)的电化学行为.结果发现,AFc对NAC的电化学氧化有很好的催化作用,该电催化氧化反应在动力学上对AFc及NAC均为一级反应,计时电流实验测得该电催化氧化反应的速率常数为(4.65±0.05)×103 mol-1·L·s-1.在AFc浓度一定时,催化氧化峰电流与NAC浓度在(0.2～4)×10-3 mol/L的范围内呈良好的线性关系(R = 0.998 9),同时运用微分脉冲伏安法对含NAC的药物进行了含量测定,测定结果令人满意.
The electrocatalytic oxidation of N-Acetyl-L-Cysteine （NAC） by acetylferrocene （AFc） at a glassy carbon electrode in 0.2 mol/L Na2SO4 aqueous solution has been studied. The electrochemical experimental resuks showed that the electrochemical response could be greatly enhanced by AFc. The electrocatalytic oxidation reaction is first-order reaction respect to NAC and AFc, respectively. Through chronoamperometric experiments, the catalytic oxidation rate constant k （4,65±0.05）×10^3 mol^-1· L· s^-1 was calculated. At the constant concentration of AFc, the catalytic peak currents was proportional to the concentration of NAC over the concentration range of 5 × 10^-5-6 × 10^-4 mol/L with a correlation coefficient of 0. 998 9. A simple difference pulse voltammetric method for the determination of NAC in pharmaceutical products has been developed and successfully applied in pharmaceutical products.
出处
《宁夏大学学报（自然科学版）》
CAS
北大核心
2005年第3期251-254,共4页
Journal of Ningxia University(Natural Science Edition)
基金
教育部科研重点基金资助项目(204191)
宁夏高校科研基金资助项目(210)
