摘要
目的:观察卡维地洛和美托洛尔对缺血性心脏病心力衰竭患者的临床疗效.方法:缺血性心脏病心力衰竭患者80例,左室射血分数(LVEF)≤0.45,心功能(NYHA)Ⅱ～Ⅳ级,常规治疗基础上随机分为卡维地洛组和美托洛尔组,治疗3月后,观察两种药物对心功能及运动耐量的影响.应用心脏彩色超声仪测定心功能基线值及3月后的变化.用6 min步行距离测定运动耐量的改善程度.结果:经过3月的治疗,卡维地洛组与美托洛尔组心率、血压、运动耐量改善程度及心功能均有明显改善,且卡维地洛组6 min步行试验结果,收缩压、舒张压变化及左室收缩末容积(LVESV)、左室舒张末容积(LVEDV)、LVEF改善程度明显优于美托洛尔组(P＜0.01).结论:在常规治疗基础上卡维地洛、美托洛尔对缺血性心脏病的治疗均有显著效果,前者在改善运动耐量、LVEDV、LVESV及心室射血方面更优.
AIM： To investigate the therapeutic effects of carvedilol and metoprolol, the β - receptor inhibitors, on cardiac function and activity tolerance in patients with ischemic heart disease and congestive heart failure （CHF）. METHODS： Eighty patients of the ischemic heart disease with CHF （LVEF ≤ 45% , NYHA of grade Ⅱ to Ⅳ）, who received the routine treatment at the same time, were randomly divided into carvedilol and metoprolol groups and treated respectively for three months. The changes of the heart function were observed by color Doppler and the activity tolerance was determined by 6 rain walking test. RESULTS： At the end of the three - month treatment, activity tolerance and the heart function of the carvedivol and metoprolol groups were remarkably improved. The left ventricular end systolic volume （LVESV）, the left ventricular end diastolic volume （LVEDV）and the LVEF of the Carvedilol group were higher than those of the metoprolol groups（P 〈 0.01 ）. CONCLUSION： Carvedilol and metoprolol are very effective in the treatment of the heart disease with CHF and carredilol is better than metoprolol in the improvement of activity tolerance, the LVESV, the LVEDV and the LVEF.
出处
《心脏杂志》
CAS
2005年第6期592-594,共3页
Chinese Heart Journal
