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斑秃患者外周血淋巴细胞凋亡的研究 被引量：2

Study on peripheral lymphocytes apoptosis in patients with alopecia areata
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摘要 目的:研究斑秃患者外周血淋巴细胞凋亡调控基因表达蛋白CD95和bcl2的表达,以探讨其在斑秃发病中所起的作用。方法:采用流式细胞仪技术检测CD95和bcl2在外周血淋巴细胞上的表达。结果:斑秃患者外周血淋巴细胞CD95表达率较正常对照组显著增高(P<0.01),而bcl2的表达率与正常对照组相比差异无显著性(P>0.05)。结论:CD95在斑秃患者外周血淋巴细胞上的表达增高,可诱导毛囊细胞快速凋亡,使斑秃在短时间内发生并促其发展。 Objective ：To study the expression of CD95 and bcl-2 in the peripheral lymphocytes and their roles in the pathogentsis of alopecia areata （AA）. Methods ：The expression of CD95 and bcl-2 on the peripheral lymphocytes were detected by flow cytometry. Results ：The expression of CD95 in AA patient was significantly higher when compared to the normal controls （P〈0.01）,whersas the expression of bcl-2 between the two groups was found no statistical significance （P〉0.05）. Conclusion ：Over-wxpression of CD95 in the peripheral lymphocytes triggers cell apoptosis in the hair follicles,which promotes the development of alopecia areata.
作者 尉雁 韩静如 董琛 王冬梅
机构地区 山西医科大学第二医院 珠海市第五人民医院
出处 《临床医药实践》 2005年第11期820-822,共3页 Proceeding of Clinical Medicine
关键词 斑秃 淋巴细胞 凋亡 CD95 BCL-2 外周血 alopecia a reata lymphocytes apoptosis CD95 bcl-2
分类号 R758.71 [医药卫生—皮肤病学与性病学]
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参考文献4

  • 1Todes-Taylor N, Turner R, Wood GS et al. T cell subpopulations in alopecia areata[J]. J Am Acad Dermatol, 1984,11 : 216-223.
  • 2Khoury EL,Price VH,Greenspan JS. HLA-DR expression by hair follicle keratinocytes in alopeciaareata:evidence that it is secondary to the lymphoid infiltration[J]. J Invest Dermatol, 1988,90 : 193-200.
  • 3Paus S,Slominski A ,Czarnetzki BM. Is alopecia areata an autoimmune-response against melanogenesisrelated proteins, exposed by abnormal MHC class I expression in the anagen hair bulb[J]? Yale J Biol Med,1994,66:541-554.
  • 4Stenn KS, Lawrence L, Veis D et al. Expression of the bcl-2 protooncogene in the cycling adult mouse hair follicle [J]. J Invest Dermatol, 1994,10a ( 1 ) : 107-111.

同被引文献26

  • 1Paus R,Brain J,Nickoloff,et al.A hairy privilege[J].Trends in Immunology,2005,26(1):32 -40.
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  • 7McElwee KJ,Freyschmidt-paul P,Zoller M,et al.Alopecia Areata Susceptibility in Rodent Models[J].J Invest Dermatol Symp Proc,2003,8(2):182-187.
  • 8Hobbs NK,Bondareva AA,Barnett S,et al.Removing the vertebrate-specific TBP N terminus disrupts placental β2m-dependent interactions with the maternal immune system[J].Cell,2002,110:43-54.
  • 9Slominski A,Pisarchik A,Tobin DJ,et al.Differential expression of a cutaneous corticotrophin-releasing hormone system[J].Endocrinology,2004,145,941-950.
  • 10McElwee KJ,Hoffmann R,Freyschmidt-paul P,et al.Resistance to alopecia areata in C3H/HeJ mice is associated with increased expression of regulatory cytokines and a failure to recruit CD4^+ and CD8^+ cells[J].J Invest Dermatol,2002,119:1426-1433.

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临床医药实践
2005年 第11期

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