摘要
目的：探讨健康成年女性不同年龄组肝代谢功能的差别。方法：用RP-HPLC检测49例18～34岁。46例35～50岁,18例51～60岁成年女性健康受试者的唾液咖啡因清除率(SCL)。结果：18～34岁年龄组的SCL在正常值范围,18～34岁年龄组、35～50岁年龄组和51～60岁年龄组各组间比较,差别显著(P<0．001)。结论：女性随着年龄的增长,SCL下降,肝代谢功能减低。
Objective： To investigate the difference of liver metabolism function in healthy adult female at different ages. Methods： The saliva caffeine clearance（SCL） was determined by RP -HPLC method in 49 healthy adult females aged 18 -34 years, 46 aged 35 - 50 and 18 aged 51 - 60 years. Results： The SCL of 18 - 34 year group was normal. There was significant difference between 18 -34 year group and others （P 〈0. 001 ） ,significant difference was also found between 35 -50 year group and 51 -60 year group （P 〈 0. 001 ）. Conclusion： The SCL in female decreased with age and the liver metabolism function become lower.
出处
《药学实践杂志》
CAS
2005年第6期344-345,共2页
Journal of Pharmaceutical Practice
关键词
成年女性
咖啡因
肝代谢功能
adult female
caffeine clearance
liver metabolism function
