摘要
目的：探讨 Galectin-3在甲状腺肿瘤组织中的表达及其临床意义。方法：运用免疫组织化学方法，检测50 例甲状腺癌(其中甲状腺乳头状癌32例，甲状腺滤泡状癌18例)、45例甲状腺腺瘤及20例正常甲状腺组织中 Galectin-3的表达。结果：50例甲状腺癌中，Galectin-3表达阳性者达45例(90． 0%)，其中29例为强阳性；45例甲状腺 腺瘤中，仅2例(4． 4%)Galectin-3阳性者，且均为弱阳性；20例正常甲状腺 Galectin-3均为阴性。Galectin-3表达阳性 率在甲状腺癌中显著高于甲状腺腺瘤及正常甲状腺(P＜0． 01) 。甲状腺乳头状癌与滤泡状癌 Galectin-3表达阳性率无 显著差异(P＞0． 05) 。淋巴结转移者 Galectin-3表达阳性率与无淋巴结转移者相比无显著差异(P＞0． 05) ，但淋巴结转移 者 Galectin-3阳性表达强度显著高于无淋巴结转移者(P＜0． 05) 。结论：Galectin-3可作为鉴别甲状腺良、恶性肿瘤的重 要参考指标，其表达强度的检测有助于甲状腺癌转移的预测。
Objective To explore the expression of Galectin-3 in thyroid tumor and its clinical significance. Methods The expression of Galectin-3 was investigated by immunohistochemistry in the tissures of 50 thyroid cancers （including 32 papillary cancers and 18 follicular cancers）, 45 thyroid adenomas and 20 normal thyroids. Results Expression of Galectin-3 was positive in 45 （90.0%） out of 50 thyroid cancers, among which it was strongly positive in 29 cases. Expression of Galectin-3 was only weakly positive in 2 （4.4%） thyroid adenomas only. Expression of Galectin-3 was negative in all 20 normal thyroids . The expression rate of Galectin-3 in thyroid cancer was significantly higher than that in adenoma and in normal thyroid （P〈0.01）. The difference between expression rate of Galectin-3 in papillary and follicular cancer was not significant （P〉0.05）. No correlation was observed between positive expression rate of Galectin-3 and lymph node metastasis （P〉0.05）, but the intensity of expression in Galectin-3 was stronger in lymph node positive cases than that in lymph node negative cases （P〈0.05）. Conclusions The expression of Galectin-3 could be regarded as an important parameter in differentiating benign and malignant thyroid tumors, and the determination of intensity of Galectin-3 expression is helpful in judging the status of lymph node metastatis in thyroid cancer.
出处
《外科理论与实践》
2005年第6期539-541,共3页
Journal of Surgery Concepts & Practice
