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埃索美拉唑治疗反流性食管炎80例 被引量：1

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摘要 目的了解埃索美拉唑对反流性食管炎的疗效与安全性。方法选择内镜确诊的反流性食管炎160例,随机分为治疗组和对照组各80例。治疗组给予埃索美拉唑,对照组给予奥美拉唑,用法均为40 mg.d-1,po,4周后均改为维持治疗,20 mg.d-1,8周为1个疗程。疗程结束后做内镜复查。结果治疗组症状明显减轻,内镜改善上效果均优于对照组,第8周治愈率分别为90.0%与85.0%。结论埃索美拉唑是反流性食管炎一线治疗药物。
作者 杨南 张幼文 王芬娟
机构地区 山东省青岛市人民医院消化内科 山东省青岛警备区第一干休所
出处 《医药导报》 CAS 2005年第12期1133-1134,共2页 Herald of Medicine
关键词 埃索美拉唑 食管炎 反流性
分类号 R975.2 [医药卫生—药品] R571 [医药卫生—消化系统]
  • 相关文献

参考文献8

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  • 2陈光宴,赵家岭,徐彬.埃索美拉唑与奥美拉唑治疗胃食管反流病临床比较[J].华北煤炭医学院学报,2003,5(4):464-464. 被引量：3
  • 3王静,侯晓华.埃索美拉唑的临床应用进展[J].胃肠病学,2003,8(2):125-126. 被引量：39
  • 4Talley NJ Lauritsen K,Tunturi-Hihnala H,Lind T,Moum B,Bang C,Schulz T,Omland TM,Delle M,Junghard O,钟捷.埃索美拉唑能有效控制内镜阴性胃食管反流症状——6个月“按需治疗”对照试验[J].中华消化杂志,2003,23(1):46-48. 被引量：6
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二级参考文献2

  • 1[1]Andersson T, Rohss K, Hassan -Alin M, et al. Pharmacokinetics(PK) and dose - response relationship of esomeprazole [ Abstract].Gastroenterology ,2000,118: A5550.
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共引文献43

同被引文献14

  • 1Kahrilas PJ, Falk GW, Johnson DA, et al. Esomeprasole improves healing and symptom resolution as compared with omeprazole in refux oesophagitis patients: a randomized controlled trial [J]. Aliment Pharmacol Ther, 2000, 14: 1249- 1258.
  • 2Richter JE, Kahrilas PJ, Johnson J, et al. Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial[J], Am J Gastuoenterol, 2001, 96 : 656-665.
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  • 4Talley NJ, Lauritsen K, Tunturi-Hihnala H, et al. Esomeprazole 20rag maintains symptom control in endoscopy-negative gastrooesophageal reflux disease: a controlled trial of "on-demand" for 6 months[J]. Aliment Pharmacol Ther, 2001,15:347-354.
  • 5Wilder-Smith CH, Rohss K, Nilsson-Pieschl C, et al. Esomeprazole 40 mg provides improved intragastric acid control as compared with lansoprazole 30 mg and rabeprazole 20 mg in healthy volunteers[J]. Digestion, 2003, 68(4) : 184-188.
  • 6Tulasssey Z, Kryszewski A, Dite P, et al. One week of treatment with esomeprazole-based triple therapy eradicates Helicobacter pylori and heals patients with duodenal ulcer disease[J]. Eur J Gastroenterol Hepatol, 2001,13 : 1457-1465.
  • 7Veldhuyzen Van Zanten S, Lufitsen K, Delchier JC, et al. One- week triple therapy with esomeprazole provides effective eradication of Helicobacter pylofi in duodenal ulcer disease[J]. Aliment Pharmacol Ther, 2000t 14 : 1605-1611.
  • 8Paul N. Maton, Nimish B. et al. Safety and Efficacy of Long Term Esoroeprazole Therapy in Patients with Healed Erosive Oesophagitis [ J ]. Drug Safety, 2001, 24 (8) : 625-635.
  • 9葛小和,谢金华,张晓红.洛赛克治疗脑出血并上消化道出血22例观察[J].现代诊断与治疗,2002,13(3):184-184. 被引量：1
  • 10Lind T,Rydberg L,Kyreback A,Jonsson A,Andersson T,Hasselgren G,Holmberg J,Rohss K,钟捷.有症状的胃食管反流病中埃索美拉唑抑酸能力比奥美拉唑更强[J].中华消化杂志,2002,22(9):558-559. 被引量：6

引证文献1

二级引证文献12

医药导报
2005年 第12期

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