摘要
目的 探讨妊娠肝内胆汁淤积症(ICP)孕妇肝胆B超特点,评价肝胆系B超检查产前预测ICP孕妇病情轻重和围 生儿预后的临床意义。方法 根据B超有无肝内胆管扩张表现将ICP孕妇分为观察组(12例)和对照组(20例),用SPSS13．0 统计软件回顾性分析两组孕妇症状的轻重和转氨酶、胆红素、胆汁酸等生化指标以及围生儿预后情况。结果观察组孕妇重 症者比例显著高于对照组(P<0．05),且瘙痒出现的时间显著早于对照组(t=2．06,P<0．05);观察组生化指标ALT、AST、 TBA、TBIL显著高于对照组(P<0．01),DBIL观察组虽有高于对照组趋势但无显著性差异(P>0．05);观察组胎儿窘迫、新生儿 窒息发生率显著高于对照组(P<0．05),分娩孕周和新生儿体重明显低于对照组(t=3．52,P<0．01;t=2．11,P<0．05)。结 论ICP孕妇若肝胆B超有肝内胆管扩张表现提示病情严重、围生儿预后差,应积极保肝利胆治疗,有条件者还可进行血浆置 换并适时剖宫产终止妊娠。
Objective： To investigate the characteristics of B ultrasonography on the liver and cholecystis and to assess it＇ s clinical value of predicting the severity degree and perinatal outcomes of patients with ICP. Methods. 32 pregnant women of ICP were divided into two groups according to the B ultrasonic imaging with or without intrahepatic cholangiectasis：the test group （12 cases） and the control group （20 cases）. The symptoms, biochemical examinations and perinatal outcomes of the two groups were analyzed retrospectively by SPSS13.0. Results： The severn cases proportion of the test group was significantly higher than that of the control group（ P 〈 0.05 ） and the skin pruritus in the test group appeared significantly earlier than the control group（ t = 2.06, P 〈 0.05） ;serum transaminase, total bile acid and total bilimbin all have significant difference between the two groups（ P 〈 0. 01 ） while no significant difference was fotmd in the direct bilimbin（ P 〉 0. 05 ） ; the incidence of fetal distress and asphyxia of newborn（ P 〈 0. 05）, the gestational age of delivery and the birth weight （ t = 3.52, P 〈 0. 01 ; t = 2.11, P 〈0. 05） all have significant difference between the two groups. Conclusion： B ultrasonic imaging with intrahepatic cholangiectasis of ICP pregnant women indicates the severe state and the poor perinatal outcomes, we should take initiative measures to treat ICP with choleretic, if possible, plasma therapy can be applied. Moreover, cesarean deliveries ought to be taken at the appropriate time.
出处
《中国优生与遗传杂志》
2005年第11期75-77,共3页
Chinese Journal of Birth Health & Heredity
关键词
胆汁淤积
肝内
妊娠
B超
Cholestasis,intrahepatic
Pregnancy
B ultrasonography
