摘要
目的比较药物去势与手术去势对前列腺癌患者血清性激素水平的影响。方法对40例行手术去势、22例药物去势(黄体生成素释放激素类似物,LHRH-A;每4周皮下注射1次)的前列腺癌患者治疗前及治疗后1、3个月血清睾酮(T)、雌二醇(E2)、孕激素(P)、卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)水平进行检测,统计学分析比较2组患者去势后性激素变化情况。结果手术去势组治疗前及治疗后1、3个月T为(19.3±10.6)、(1.1±0.8)、(0.9±0.7)nmol/L,E2为(104.3±58.4)、(53.4±36.9)、(50.7±37.5)pmol/L,P为(2.6±1.6)、(1.8±1.3)、(1.7±1.4)nmol/L,FSH为(10.8±6.5)、(73.8±31.4)、(75.1±28.7)IU/L,LH为(11.2±7.5)、(38.3±20.6)、(37.4±30.5)IU/L,PRL为(14.5±8.9)、(12.8±7.6)、(13.2±7.9)μg/L;药物去势组治疗前及治疗后1、3个月T为(21.1±11.7)、(1.2±0.7)、(1.0±0.6)nmol/L,E2为(110.5±62.7)、(36.5±30.4)、(34.7±28.6)pmol/L,P为(2.7±1.4)、(0.8±0.6)、(0.7±0.6)nmol/L,FSH为(11.2±7.0)、(5.5±4.3)、(5.8±4.0)IU/L,LH为(12.0±6.7)、(0.8±0.4)、(0.7±0.4)IU/L,PRL为(15.2±7.6)、(13.8±8.2)、(14.2±9.4)μg/L。2组治疗1个月后,T值均显著下降。药物去势治疗后FSH、LH明显下降,而手术去势后FSH、LH明显上升。药物去势组治疗后E2、P下降程度大于手术去势组。结论药物去势与手术去势对前列腺癌患者的性激素水平可产生不同影响。
Objective To compare the effects of medical and surgical castration on serum hormones in patients with prostate cancer. Methods A total of 62 patients with prostate cancer were included. Of them 40 patients were treated with surgical castration （bilateral orchectomy ） and 22 patients were treated with medical castration （LHRH-A, subcutaneous injection once every 4 weeks）. The serum testosterone （T） , estradiol （ E2 ） , progestin （ P ） , follicle -stimulating hormone （ FSH ） , luteinizing hormone （ LH ） and prolaetin （PRL） levels of these patients were measured and compared before treatment and 1 month, 3 months after treatment, respectively. Results Before treatment and 1, 3 months after treatment, the serum T levels were （19.3±10.6）、（1.1±0.8）、（0.9±0.7）nmol/L,the E2levels were（104.3±58.4）、（53.4±36.9）、（50.7±37.5）pmol/L,the P levels were（2.6±1.6）、（1.8±1.3）、（1.7±1.4）nmol/L,the FSH levels were（10.8±6.5）、（73.8±31.4）、（75.1±28.7）IU/L,the LH levels were（11.2±7.5）、（38.3±20.6）、（37.4±30.5）IU/L,the PRL levels were（14.5±8.9）、（12.8±7.6）、（13.2±7.9）μg/L;respectively,in surgical castration group. In medical castration group, before treatment and 1,3 months after treatment, the serum T levels were（21.1±11.7）、（1.2±0.7）、（1.0±0.6）nmol/L,the E2 level were（110.5±62.7）、（36.5±30.4）、（34.7±28.6）pmol/L,the P levels were（2.7±1.4）、（0.8±0.6）、（0.7±0.6）nmol/L,the FSH levels were（11.2±7.0）、（5.5±4.3）、（5.8±4.0）IU/L,the LH levels were（12.0±6.7）、（0.8±0.4）、（0.7±0.4）IU/L,the PRL levels were（15.2±7.6）、（13.8±8.2）、（14.2±9.4）μg/L.2; ,respeetively. It was shown that 1 month after treatment, T levels declined signifi- cantly in both groups. FSH and LH levels declined significantly in medical castration group, while increased in surgical castration group （P 〈 0.01 ）. Serum E2 and P levels 1 month after treatment decreased more markedly in medical castration group than those in surgical castration group （P 〈 0.01 ）. Conclusions The effects of medical or surgical castration on serum hormone levels are different in patients with prostate cancer.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2005年第12期812-815,共4页
Chinese Journal of Urology
关键词
前列腺癌
性激素
去势
Prostate cancer
Sex hormone
Castration
