摘要
应用放射免疫双抗体法测定了126例急性心肌梗塞患者的血清铁蛋白（SF）浓度，探讨了SF浓度与梗塞面积之间的关系及心肌梗塞后SF的变化规律。结果：大面积梗塞组SF浓度（279．42±99．28μg／L）明显高于中等面积梗塞组与小面积梗塞组（SF分别为202．13±76．97μg／L和173．69±49．69μg／L），心肌梗塞后第7天SF达高峰（246．87±115．62μg／L），心肌梗塞后第28天SF恢复基线水平（168．40±50．90μg／L），不同时期的SF浓度比较具有显著性差异（P＜0．05）。作者认为：心肌梗塞面积越大，SF浓度越高，心肌梗塞发生后SF浓度呈动态变化过程，监测SF可作为诊断急性心肌梗塞，估测梗塞面积的辅助指标。
In order to investigate the relation between serumferritin (SF) level and infarct size as well as dynamicchanges in acute myocardial infarction (AMI), the SFlevels were determined by radioimmunal double antibodytechnique in 126 patients with AMI. The resultsshowed that SF levels were 279. 42±99. 28μg/L,202. 13± 76. 97μg/L and 173. 69±49. 69μg/L in large,medium and small size of infarct,respectively. The SFlevel in large size group was significantly higher thanthat in other groups (F = 10. 3480, P =0. 0001 ). Thedynamic changes in SF levels were 166. 60±74. 04μg/L, 193. 38± 96. 17μg/L, 203. 66±87. 58μg/L, 232. 08±94. 79μg/L, 246.87± 115. 62μg/L, 234. 16± 102. 02μg/L, 184. 28± 75. 62μg/L and 168. 40±50.90μg/L at 6h,12h, 24h, 72h and on 7d, 14d, 21d and 28d after the onsetof AMI,respectively. Elevation of SF began at the12th hour, peak at the 7th day, and returned to thebaseline on the 28th day. There was a statistical significancebetween various phases of AMI(F= 2. 8333,P=0.0115 ). The results showed that the bigger the size ofmyocadial infarction,the higher the SF value, and theSF change during the acute phase of myocardial infarctionappeared to be a dynamic course,1t is suggestedthat monitoring SF is helpful to the diagnosis of AMIand to the estimation of infarct size.
出处
《中国危重病急救医学》
CAS
CSCD
1996年第7期407-408,共2页
Chinese Critical Care Medicine
基金
河北省卫生厅科研基金
关键词
铁蛋白
血清
心肌梗塞
急性
serum ferritin
acute myocardial infarction
size of myocardial infarct
dynamic change
