摘要
采用Ｃ５７ＢＬ小鼠和Ｌｅｗｉｓ肺低分化癌细胞株进行瘤苗主动免疫疗法的实验研究。结果表明：（１）单纯瘤苗注射组１０只动物的瘤苗注射区及各脏器均未见肿瘤生长。各脏器也未见明显病理改变；（２）瘤苗注射治疗Ｄ组植入１×１０５癌细胞，植入区与各脏器均未见癌生长。而治疗Ｃ组植入２×１０７癌细胞，植入区均有瘤结生长，但瘤结体只明显小于对照组（０．０４１ｃｍ３：０．４３１ｃｍ３），肺只有１只动物有一个转移瘤结（对照组９只肺有１～２个转移瘤结）；（３）从Ａ组瘤苗注射区及其他组瘤结印片观察显示有巨噬细胞吞噬活跃，癌细胞周围有许多巨噬细胞、淋巴细胞侵蚀癌细胞现象。表明瘤苗的抑瘤作用可能主要通过细胞免疫来完成。
In this article C_(57)BL mouse and Lews lower differentiated lung cancer cell line were adopted to conduct the experimental studies on active immunotherapy with tumour vaccine. The results showed:(1) Tumour formation was not found in injection site and other organs in ten mice with injection of tumour vaccine only, obviously patholongic changes were not seen in other organs;(2)1×10￣5 cancer cells were implanted in the treated D group with injection of tumour vaccine precedingly, tumour growing was not seen in implantation site and other organs;while tumour tubercles were found ineach implantation site of treated C group mice in which 2×10￣7 cancer cells were impanted, But the volume of tumour tubercles was distinctly smaller than that in the control group, only one mouse had one metastatic tumour tubercle in lung (In the control group nine mice had one or two tumour tubercles for each).(3) The sections prepared from all groups showed that phagocytosis of macrophages was active and there were many macrophages around cancer cells and lymphocyte was erosing cancer Cells. These phenomen aindicated that the inhibitory function of tumour vaccine to tumour may be a ccomplished through cellular immunity.
出处
《中国人兽共患病杂志》
CSCD
北大核心
1996年第3期30-32,共3页
Chinese Journal of Zoonoses
关键词
瘤苗
主动免疫
免疫疗法
Tumour vaccine
Active immunothreapy
Experimental study
