摘要
应用高效液相色谱法检测原发性肝癌、肝硬化和正常对照组尿液假尿苷含量。结果表明，肝癌组尿液假尿苷含量比正常对照组有明显升高（Ｐ＜０．０１），比肝硬化组也有升高（Ｐ＜０．０５），肝癌尿液假苷与血清ＡＦＰ联合检测诊断阳性率明显高于血清ＡＦＴ（Ｐ＜０．０１）。提示：尿液假尿苷对肝癌诊断是有用的指标，与血清ＡＦＰ联合检测可提高肝癌诊断阳性率，尤其是ＡＦＰ阴性或低浓度升高的肝癌的诊断。
e detected the level of urinary pseudouridine in patients with primary hepatic carcinoma(PHC),liver cirrhosis(LC) and normal persons,using high performance liquid chromatography technique;Theresults demonstrated that urinary pseudouridine level in PHC patients was significantly higher than thatin normal persons(P< 0.01) and LC patients(P< 0.05).Positive rate of diagnosis in combine deter-mination of urinary pseudouridine and serum AFP with PHC was significantly higher than serum AFP(P<0.01).These results suggested that urinary pseudouridine would be an useful tumor marker andcombine determination of urinary pseudouridine and sernm AFP elevate positive rate in the diagnosis ofPHC, particularly of AFP negative or with elevated lower concentration.
出处
《中国医科大学学报》
CAS
CSCD
1996年第2期142-144,共3页
Journal of China Medical University
关键词
肝肿瘤
原发性肿瘤
标志物
假尿苷
诊断
primary hepatic carcinoma
tumor marker
urinary pseudouridine
