摘要
为了解精神分裂症患者局部脑血流(rCBF)变化,用心理测验"第四例外"法激活大脑额叶功能,以^(99m)Tc-乙撑双半胱氨酸二乙酯SPECT显像研究22例精神分裂患者及10例健康人休息与激活状态rCBF变化。结果休息状态下,精神分裂症组有4例左侧大脑半球高灌注,其额叶不能被激活;余18例休息状态rCBF与对照组无明显差别;对照纽额叶被激活,病例组左额叶激活不明显。表明精神分裂症患者可能存在额叶功能障碍。
PURPOSE Regional cerebral blood flow (rCBF) changes of the patients with schizophrenia were observed. METHODS ^(99m)Tc-ECD SPECT was performed on 22 patients with schizophrenia and 10 healthy volunteers at rest and activation with a cognitive task: a modified Wisconsin Card Sorting Test. RESULTS At rest state, only 4 patients have abnormal rCBF pattern: left hemisphere over-perfusion relative to the right. A significant relative activation deficit in the left inferior prefrontal region was revealed in the patients during activation. CONCLUSIONS The patients with schizophrenia may have frontal lobe dysfunction.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
1996年第2期109-111,共3页
Chinese Journal of Nuclear Medicine
关键词
精神分裂症
脑血流
CT
休息
激活
Schizophrenia Brain Regional blood flow Tomography,emission computed,single photon
