摘要
首次以对甲苯磺酰氯和肌醇为原料,合成了1,2,3,5-四对甲苯磺酸肌醇酯,讨论了多重因素对酯化反应收率的影响,并对其结构进行了确定.结果表明,获得1,2,3,5-四对甲苯磺酸肌醇酯的最佳的反应条件为:以10 ml吡啶为溶剂兼催化剂,对甲苯磺酰氯与肌醇的摩尔比为0.021 0∶0.005,反应时间为4 h,反应温度为0～10 ℃,收率可达49.7%.
This paper deals with inositol tetra-tosylate synthesized from inositol and p-toluene sulfonylchloride in one step for the fist time. Factors influencing the yield of esterfication reaction were discussed . Under the optimal condition that the molar ratio of p-toluene sulfonylchloride is 0. 021 0 ： 0. 005,the volume of pyridine as solvent and catalyzer is 10 ml, the time of reaction is 4h, and temperature range of reaction is from 0℃to 10℃, the highest yield ester can reach 49.7%. Its structure was confirmed by IR,^1H NMR , MS and Elemental Analysis.
出处
《河南师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第4期87-89,共3页
Journal of Henan Normal University(Natural Science Edition)
基金
河南省科技厅科技攻关项目(0324260104)
关键词
肌醇
对甲苯磺酰氯
合成
inositol
p-toluene sulfonylchloride
synthesis
