摘要
目的探讨PTEN表达与肝细胞癌发生、发展的关系。方法检测PTEN在肝癌组织和肝癌细胞系中的表达情况,以观察该基因与肝癌病理分级、转移和预后的关系。结果肝癌中PTEN表达阴性率为30.16%(19/63),显著高于正常肝组织0(0/8)和肝硬化组织7.15%(1/14)。随着恶性程度的增高,PTEN表达阴性率随之增加。PTEN表达阴性与是否转移及预后显著相关。PTEN在人肝癌细胞系HHCC中也不表达。结论抑癌基因PTEN低表达多见于肝细胞肝癌进展期,并与肝细胞肝癌分化程度、是否转移以及临床预后相关。
Objective To investigate the relationship between the loss of expression of PTEN and the HCC development and malignancy. Methods We examined the expression of PTEN protein on archival HCC materials and hepatocelluar carcinoma cell line . Results PTEN protein was detected in 19 out of 63 cases of HCC, much higher than that of normal liver tissues and cirrhotic liver tissues. The negative rate has a statistical significant relationship with the difference, metastasis and prognosis. Conclusion Loss of tumor suppressor PTEN protein expression usually occurs in HHCC pathologic progression and is correlated with differentiation, metastasis and prognosis.
出处
《现代肿瘤医学》
CAS
2005年第6期746-747,共2页
Journal of Modern Oncology
