摘要
目的探讨老年2型糖尿病患者高尿酸血症的临床特征。方法将256例2型糖尿病住院患者分为老年糖尿病组(老年组)168例和非老年糖尿病组(非老年组)88例并选择37例无糖尿病老年人作为对照(对照组)。分别记录年龄、性别、体重指数、糖尿病病程,检测血清尿酸及肌酐,尿尿酸及肌酐、尿pH,计算24h尿尿酸排泄总量、尿酸清除率、肌酐清除率、尿酸清除分数等,3组间进行比较。结果老年组血清尿酸水平显著高于非老年组和对照组(均为P<0.01);而肌酐清除率〔(52.8±28.5)ml/min〕低于非老年组〔(89.9±34.3)ml/min〕(P<0.01)和对照组〔(57.9±37.6)ml/min〕(P<0.05),尿pH值下降,24h尿量增加。非老年组尿酸清除率〔(7.63±4.80)ml/min〕显著高于老年组〔(4.47±3.60)ml/min〕和对照组〔(3.75±3.20)ml/min〕(P<0.01);24h尿酸排泄量显著高于老年组和对照组(均为P<0.01)。结论老年组血清尿酸水平与年龄、血清肌酐、尿酸清除率、24h尿尿酸排泄量相关,尿酸生成增多、尿酸清除能力减退及尿量减少、尿pH值减低等多种因素共同导致老年2型糖尿病患者高尿酸血症。
Objective To explore the correlation factors of hyperuricemia in elderly patients with type 2 diabetes mellitus（T2DM）. Methods Two hundred and fifty-six inpatients with T2DM were divided into elderly（n= 168）and non elderly（n= 88）groups. Another 37 elderly non-DM cases were as control. The parameters of serum uric acid and creatinine, urinary uric acid, pH and creatinine, clearance rates of uric acid and creatinine（Ccr）were determined and compared among 3 groups. Results The elderly T2DM group had higher level of serum uric acid than did non-elderly T2DMand control groups（all P〈0.01）, and lower Ccr[（52.8±28.5）vs（57.9±37.6）ml/min], urinary pH lower and 24 h hour urine volume higher than did control group（all P〈0.01）. Non-elderly T2DM group had more urinary uric acid amount in 24 hours（P〈0.01）higher clearance rate of uric acid [ （ 7.63 ±4.80） ml/min] than did elderly T2DM group [ （4.47 ± 3.60 ） ml/min] and control group [（3.75±3.20） ml/min] （all P〈0.01）. Conclusions The hyperuricemia in elderly patients with T2DM is correlated with its lower clearance rate of uric acid and urine amount in 24 hours than those in non-elderly patients with T2DM group and normal control.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2005年第10期733-735,共3页
Chinese Journal of Geriatrics
关键词
糖尿病
2型
尿酸
痛风
Diabetis Mellitus type 2
Urine acid
Gout
