摘要
为观察阿苯达唑连续治疗肝泡球蚴病伴梗阻性黄疸的临床疗效，对６例患者采用阿苯达唑每日每公斤体重２０ｍｇ连续治疗。结果黄疸均于治疗后１～２．５个月消退，血清胆红质逐渐降至正常。治疗前Ｂ超或（和）ＣＴ检查均显示肝内不均质实质性病变，肝门区模糊，胆总管或右叶胆管未显影，肝内胆管明显扩张。１例伴有胆总管与胰管扩张，脾静脉增粗，脾显著肿大。２例分别于停药后９年和３年复查时，肝内病变几乎完全钙化，可能治愈。４例仍在治疗中。治疗１年时复查，６例肝内病变明显好转，肝内胆管扩张消失。肝功能复查，除２例球蛋白升高外，均转为正常。表明阿苯达唑治疗肝泡球蚴病伴梗阻性黄疸有较好效果，长期连续治疗未见明显毒副反应。
Toobserveclinicalresultsofcontinuoustherapywithalbendazoleforhepaticalveolarechinococosisasociatedwithobstructivejaundice,wetreated6patientscontinuouslywithalbendazoleatadosageof20mg·kg-1·d-1.Jaundicedisappearedandserumbilirubinlevelreturnedtonormalwithin1～2.5monthsinthepatients.Ultrasoundand/orCTscanningofliverbeforetreatmentdisplayediregularheterogenouslesions,obscurehilarregionwithmarkedintrahepaticbiliarydilatation.Inoneseverejaun-dicedpatient,thecommonbileductandthepancreaticductweredilatedandtheportalandsplenicveinswerealsodistendedwithmarkedsplenomegaly.Twopatientswerefolowedupfor3～9yearaftercessa-tionoftreatment,theirhepaticlesionswerealmostcompletelycalcifiedandconsideredcured.Theotherfourpatientswerestilsubjectedtotreatmentoneyearlater.CTandultrasoundscanningshowedmarkedimprovementofintrahepaticlesionsanddisappearanceofintrahepaticbiliarydilatation.Liverfunctiontestsreturnedtonormalexceptthatserumglobulinremainedelevatedin2cases.ClinicalobservationandCTscanningofliverindicatedthatcontinuoustherapywithalbendazoleisefectiveinthetreatmentofhepaticalveolarechinococosisassociatedwithobstructivejaundice.Noadversesidereactionsweresen.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1996年第4期261-264,共4页
Chinese Journal of Internal Medicine
