摘要
目的观察酮对高胆固醇血症大鼠血脂的影响。方法预防性给药实验中,动物灌胃胆固醇乳剂诱发高胆固醇血症,酮(10、30及90mg/kg)在胆固醇处理前两天给予,连续用药12天;治疗性给药实验中,高脂饲料喂养一月后,大鼠灌胃酮(10、30及90mg/kg)3周。结果预防性和治疗性给予酮均能降低高胆固醇血症大鼠血清总胆固醇和低密度脂蛋白水平。治疗性给药实验中,酮能显著降低血清丙二醛水平。结论酮能降低高胆固醇血症大鼠血脂和丙二醛水平。
Aim To test the effects of Xanthone on the serum lipids and oxidative state of hypereholesterolemie rats. Methods In the preventive experiment, the rats were treated with Xanthone （ 10, 30 and 90 mg/kg） for 2 days and then treated with cholesterol for 10 days in the presence of Xanthone; In the therapeutic experiment, after the rats were fed with food containing eholesterol for 4 weeks to induce hypereholesterolemia, the animals were treated with Xanthone for 3 weeks. Serum lipid and malondialdoliyde were measured. Results Xanthone, given preventively or therapeutically, markedly decreased total eholesterol and low density lipoprotein eholesterol level. Moreover, in the therapeutie experiment, xanthone also decreased malondialdohyde content. Conclusion Xanthone could decrease serum lipid and malondialdohyde level of hypereholesterolemie rats.
出处
《中国动脉硬化杂志》
CAS
CSCD
2005年第3期317-319,共3页
Chinese Journal of Arteriosclerosis
基金
湖南省自然科学基金(02jjy2046)
