摘要
目的探讨血管内皮细胞生长因子(VEGFmRNA)和碱性成纤维细胞生长因子(bFGFmRNA)在原发性胃癌中的表达及意义。方法应用原位杂交技术检测56例胃癌患者VEGFmRNA和bFGFmRNA的表达情况。结果胃癌患者VEGFmRNA和bFGFmRNA表达水平明显高于正常人,与胃癌血管侵犯、淋巴结受累、肝脏转移及临床病理分期密切相关,与肿瘤大小、部位、年龄、性别、生长方式及组织学类型等因素无关。结论VEGFmRNA和bFGFmRNA表达水平与胃癌的浸润、转移密切相关,可作为原发性胃癌的预后指标,可望为抑制原发性胃癌血管生成治疗提供实验依据。
Objective To study the expression and significance of VEGF - mRNA and bFGF - mRNA in gastric cancer. Methods The expression of VEGF-mRNA and bFGF-mRNA was investigated by in situ hybridization. Results The expression of VEGF-mRNA and bFGF-mRNA in gastric cancer was significantly higher than that of normal control. With upgrading of the e.linical-patholgical stage（ Dukes＇s stage） , the expression of VEGF-mRNA and bFGF-mRNA increased significantly, but its relation to tumor size, site, age, sex, growth pattern and histological type was not significant, Conclusion The expression of VEGF-mRNA and bFGF-mRNA is colsely correlated to invasion and metastasis of gastric cancer. In the present study,it provides experimental and new clue for anti -angiogensis.
出处
《临床医学》
CAS
2005年第11期16-18,共3页
Clinical Medicine
