摘要
目的研究有机磷农药氧化乐果对小鼠睾丸细胞DNA的损伤作用。方法24只昆明小鼠随机分成4组(对照组、1、2、4mg/kg染毒组),每组6只。经口染毒7d,用彗星试验技术(SCGE)检测小鼠睾丸细胞DNA的损伤。结果1、2、4mg/kg氧化乐果暴露的小鼠睾丸细胞彗星尾长和彗星尾长与头长之比均大于对照组(P<0.01),且随氧化乐果染毒剂量的增加,睾丸细胞彗星尾长也增加,具有剂量鄄效应关系。结论氧化乐果可引起小鼠睾丸细胞DNA的损伤。
Objective To study the adverse effect of omethoate on DNA in mice testicle cells in vivo. Methods 24 mice were randomly divided to 4 groups： control（no omethoate）, 1, 2 and 4 mg/kg, omethoate was g/yen by garage one time a day for consecutive 7 days. DNA damage was detected by single cell gel electrophoresiss （SCGE）. Results At the concentration of 1, 2, 4 mg/kg, omethoate induced DNA damage in mice testicle cells in vivo with an obvious dose-effect relationship （r=0.969 5）. Conclusion Omethoate may cause DNA damage in mice testicle cells.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2005年第6期468-469,共2页
Journal of Environment and Health
基金
北京市教委科技发展项目(KM200411417001)
