加味散结镇痛方对实验性子宫内膜异位症大鼠血管内皮生长因子的影响被引量：9

Influence of Jiawei Sanjie Zhentong Recipe on Vascular Endothelial Cell of Experimental Rats with Endometriosis

导出

摘要目的:探讨血管内皮生长因子(VEGF)在子宫内膜异位症(EM)发病机制中的作用及相互关系,观察加味散结镇痛方对实验性EM大鼠VEGF的影响及对EM的治疗作用。方法:采用自身内膜种植方法建立EM动物模型,给予加味散结镇痛方治疗,并设达那唑对照组。免疫组化SABC法检测VEGF表达。结果:模型组异位内膜组织中VEGF的含量表达显著提高,与正常对照组比较有统计学差异(P<0.01);加味散结镇痛方能降低大鼠病变组织中VEGF含量表达,与模型组比较有统计学差异(P<0.01,P<0.05)。结论:VEGF在EM发生、发展中有高表达,加味散结镇痛方可通过调节VEGF的表达来抑制异位内膜的生长,起到一定的治疗作用。

作者吴献群李海棠黄虹

机构地区湖北中医学院湖北中医学院附属医院

出处《湖北中医杂志》 2005年第11期3-5,共3页 Hubei Journal of Traditional Chinese Medicine

关键词子宫内膜异位症中医药疗法加味散结镇痛方血管内皮生长因子

分类号 R285.5 [医药卫生—中药学]

引文网络
相关文献

参考文献6

1殷红梅,王苏荣,戴淑真,王秋波.子宫内膜异位症患者T辅助细胞亚群功能失衡的研究[J].中华妇产科杂志,2000,35(6):327-328. 被引量：17
2肖纯,黄桂林,刘小刚,余跃飞,黄越燕.证、病结合的子宫内膜异位症动物模型的复制[J].中国实验动物学杂志,2002,12(3):157-160. 被引量：23
3Guldi Aj, Abu-Jawdeh G, Tognazzi K,et al. Expresson of vascularper meability factor( vascular endothelial growth factor) and its reoetors in endometrial carcinoma[J]. Cancer, 1996,78:454-460.
4辛晓燕,李洁,严瑞兰,王德堂.血管生成因子在子宫内膜异位症中的作用[J].现代妇产科进展,2001,10(3):187-189. 被引量：20
5颜永书.血竭及其活血化瘀功能浅谈[J].湖南中医杂志,1999,15(6):60-60.
6郝桂敏,江静,王振海,曹冬冬,吴瑞芳.达那唑治疗子宫内膜异位症患者血中雌二醇、血管内皮生长因子及癌标记抗原的变化[J].中国综合临床,2002,18(6):566-567. 被引量：1

二级参考文献17

1肖纯,黄桂林,彭泽华,匡冰.大鼠实验性子宫内膜异位症模型复制[J].中国病理生理杂志,1995,11(3):332-333. 被引量：20
2陈奇.中药药理实验[M].贵阳:贵州人民出版社,1998.80.
3[1]Giudice,Tazuke S, Swiersz L .Status of current research on endometriosis[J] .J Reprod, 1998,43(3 Suppl):252-262
4[2]Sampson J. Peritoneal endometriosis due to mentral dissemination of endometrial tissue into the peritoneal cavity[J].Am J Obstet Gynecol, 1927,14:422-469
5[3]Venrini PL,Semino A,Dec Cecco L.The biological basis of medical treatment of endometriosis[J]. Gynecol Endocrinol,1995,9:259-266
6[4]Heldin CH, Westemark B. Platelet-derived growth factor:Mechainsm of action and possible in vivo function[J]. Cell Regul, 1990,1:555-566
7[5]Mclaren J,Prentice A,Chamock-Jones DS, et al. Vescular endothelial growth factor(VEGF)concentrations are elevated in peritoneal fluid from women with endometriosis[J]. Hum Reprod, 1996,11:220-223
8[6]Osteen KG, Hill GA, Hargrove JT, et al. Development of a method to isolate and culture highly purified populations of stromal and epithelial cells from human endometrial biopsy specimens[J]. Fertil Steril, 1989,52:965-972
9[7]Gasparini G, Harris A. Clinical importance of the determination of tumor angiogenesis in breast carcinoma:Much more than a new prognostic tool[J].J Clin Oncol,1995,13:765-782
10[8]Folkman J.Seminars in medicine of the Beth Israel. Hospital,Boston. Clinical applications of research on angiogenesis[seecomments][J].N Engl J Med,1995,233:1757-1763