摘要
采用猪-犬肾移植建立超急性排斥反应模型，以研究此时的血液流变学变化。分别在移植前、移植肾超急性排斥发生时和排斥肾切除后10～15分钟检测外周血的血液流变学参数变化。结果异种肾移植发生超急性排斥时，血小板聚集显著增高，移植肾切除后血中的血小板数和纤维蛋白原明显下降，血小板聚集也恢复原有水平。提示血小板、纤维蛋白原参与了异种移植超急性排斥反应的发生过程，而血小板聚集可能是诊断异种移植超急性排斥反应一个有价值的指标。
Ten kidney xenograftings were performed in dog to pig combination. Hemorrheological parameters were detected respectively be fore transplantation, at the hyperacute rejection and at 10~15 minutes after the removal of the rejected kidneys. The results showed that platelet aggregation increased significantly in hyperacute rejection. Platelet and fibrinogen decreased significantly and the platelet aggregation recovered at 10~ 15 minutes after rejected kidneys were removed. It is indicated that the platelet and fibrinogen participate in the hyperacute xenograft rejection, and that platelet aggregation may provide a voluable and sensitive assay for hyperacute xenograft rejection.
出处
《中华器官移植杂志》
CAS
CSCD
1996年第1期6-8,共3页
Chinese Journal of Organ Transplantation
关键词
移植免疫学
急性排斥
血液流变学
异体移植
Transplantation, heterologous
Hyperacute rejection
Hemorrheology
