摘要
为了研究原发性肝癌对手术之耐受力,自1980至1987年,对358例原发性肝癌术前作γ-谷氨酰转肽酶(γ-GT)活性,血清谷丙转氨酶(SGPT),血清蛋白比值,术中所见肝硬化程度,肿瘤大小,以及各种术式与术后出现肝功能代偿不全的关系作多元回归分析,结果表明:术前γ-GT活性越高,术后肝功能代偿不全发生率越高(P<0.01)。γ-GT活性可作为术前肝手术耐受力的指标,当γ-GT小于40 U％时,基本可作各手术术式;γ-GT>200U％者,结扎肝动脉术要慎重;γ-GT>200U％时,右肝切除术都要慎重;当γ-GT>300u％时,任何术式,即使是剖腹探查,也会出现术后肝功能代偿不全,术后也未能提高病人的生存期。
The serum γ-glutamyl-transpeptidase activity (γ-GT ), serumSGPT and albumin Globulin ratio had been determined in 358 cases of primary liver carcinoma (PLC ) before operation in our department. Multi-factorial regression analysis had been done for the relationship of the degree of hepatic cirrhosis. tumor size, the types of hepatectomy and postoperative liver failure. The results showed that the higher is the γ-GT activity, the higher is the incidence of the postoperative liyer failure (P <0.01) . There for the serum γ-GT activity is a good cirterion for the evaluation of preoperative reserve function of the liver. When the γ-GT activity is <40u%, usually all, types of hepatectomy can be performed. When γ-GT is >200u%,any hepatectomy of the right lobe should be done with cantion. Wheny-GT is > 300u% , the patient can not tolerate even JaParotomy, and the survival time can not be prolonged.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第5期375-378,共4页
Chinese Journal of Cancer
