摘要
目的探讨苦参碱治射液对慢性乙型肝炎患者外周血T细胞免疫的影响。方法采用SAP法检测30例慢性乙型肝炎患者外周血T细胞亚群。结果有2例感染者达到完全应答,12例部分应答,16例无应答;苦参碱治疗后外周血CD3+T细胞较治疗前明显增高,应答组CD4+T细胞显著高于无应答组。结论用苦参碱治疗慢性乙型肝炎患者可以影响患者T细胞免疫,使患者CD4+T细胞水平明显增高。
Objective To investigate the effect of Kushenjian injection on the cellular immunity in peripheral blood in 30 patients with chronic hepatitis B virus （HBV） infection, Methods T cell subpopulation （TCS） in the peripheral blood of the patient were respectively examined by SAP. Results There were 2 complete responder （CR）, 12 partial responders （PR） and 16 non- responder（NR） at the end of Kushenjian injection treatment. The serum ALT and AST of the patients treated with Kushenjian were dramatically decreased compared with pretreatment （P〈0.05）. The percentage of CD3＋TLC in peripheral blood were increased remarkably after ttreatment. And CD4＋ cells were also amplified significantly in CR or PR than in NR group. Conclusions Therapy with Kushenjian injection can im- prove the T cell especially CD4＋T in peripheral blood in patients with chronic HBV infection.
