摘要
应用特异性单克隆抗体荧光偏振免疫法（ＭＡＦＰＩＡ）对６８例肾移植患者进行３６２次临床环孢素Ａ（ＣｓＡ）全血药物浓度监测。结果表明：合并用药会影响ＣｓＡ全血浓度。术后时间与ＣｓＡ全血浓度有一定关系。ＭＡＦＰＩＡ是一种简便、快速、准确的监测方法，对指导临床鉴别排异与中毒反应以及个体化给药，具有重要意义。
Whole blood concentration of CsA was determined by MAFPIA for 362 times in 68 renal transplantation patients.The results showed that drug combination and the time of post-operation could influence CsA blood concentration。MAFPLA is simple,rapid,accurate.We conclude that the monitoring of CsA by MAFPIA is important to deciding drug administration and make differential diagnosis between renal toxicity of the drug and rejection reaction.
出处
《西安医科大学学报》
CSCD
1996年第1期77-79,共3页
Journal of Xi'an Medical University(Chinese)
关键词
环孢素A
血药浓度
MAFPIA
免疫抑制剂
cyclosporine A
fluorescence polarization immunoassay
whole blood concentration monitoring
