摘要
目的观察硝普钠对扩张型心肌病(DCM)患者充血性心力衰竭的疗效.方法选择DCM病人72例,随机分成硝普钠组和对照组各36例,对照组按常规治疗,即卧床休息,吸氧,限制钠盐摄入,应用利尿剂、ACEI、强心剂等.治疗组在常规治疗基础上加用硝普钠25～50mg加5%葡萄糖液500ml,持续静脉滴注24h,治疗5天,对比两组患者用药前后NYHA心功能级别和心脏指数即心脏左室射血分数(EF)、心输出量(CO)及心脏舒张功能指标E峰与A峰比值(E/A)的变化.结果硝普钠治疗组显效(心功能改善Ⅱ级以上)23例,显效率63.9%;常规治疗组显效10例,显效率27.8%,两组相比较,差异有显著性.硝普钠治疗组和常规治疗组治疗前后心脏左室射血分数(EF)、心输出量(CO)及心脏舒张功能指标E峰与A峰比值(E/A)的相比,差异有统计学意义.结论硝普钠对改善DCM患者心力衰竭疗效显著.
Objective To observe the curative effect of sodium nitroprusside on congestive heart failure in patients with dilated cardiomyopathy. Methods 72 patients with dilated cardiomyopathy were selected and were randomly divided into two groups： the routine therapy group and the sodium nitroprusside group ; the first group with 36 patients was given bed rest, oxygen inhale, diuretic, angiotension Ⅱ converting enzyme inhibitor （ ACEI ）, cardiotonic and et al., while the second group with 36 patients was given sodium nitroprusside 3 ～ 5μg/kg·min on the basis of routine therapy;The difference between the two groups in left ventricular ejection fraction,cardiac output and cardiac relaxation function index E/A ratio （E and A peak ratio ） before the treatment and 5 days after treatment was compared. Results The cardiac function improved rate （over 2 classes） in sodium nitroprusside therapy group was 63.9% while that in routine therapy group was 27.8% ,there existed great differences between the two groups in left ventricular ejection fraction, cardiac output and cardiac relaxation function index E/A ratio （ P 〈 0.05）. Conclusions Sodium nitroprusside can improve cardiac function in patients with dilated cardiomyopathy.
出处
《西南军医》
2005年第5期35-37,共3页
Journal of Military Surgeon in Southwest China
关键词
心力衰竭
充血性
扩张型心肌病
硝普钠
heart failure congestive dilated cardiomyopathy sodium nitroprusside
