摘要
为探讨抗雌激素药物三苯氧胺（ＴＡＭ）对外源性雌激素致乳癌危险因素的阻断作用。作者将雌性大鼠分为三组：己烯雌酚组、己烯雌酚加ＴＡＭ组、空白对照组。实验结果：己烯雌酚加ＴＡＭ组血清雌二醇和孕酮水平明显高于己烯雌酚组（Ｐ＜０．０５，Ｐ＜０．０１）；乳腺增生率显著低于己烯雌酚组（Ｐ＜０．０２５），增生程度明显轻于己烯雌酚组（Ｐ＜０．０２５）；ＡｇＮＯＲ计数、ＤＮＡ含量以及ＥＲ含量和阳性率明显低于己烯雌酚组（Ｐ＜０．０５），而与对照组无显著差别。结果提示：ＴＡＭ可增加血清雌二醇、孕酮水平，抑制己烯雌酚所致的ＤＮＡ和ＡｇＮＯＲ量变，拮抗雌激素刺激的ＥＲ合成，从而阻断外源性雌激素致乳癌的危险因素。
Inordertoinvestigatetheinhibitoryefectoftamoxifen(TAM)onbreastcancerriskin-ducedbyexogenousestrogen,femaleratswererandomlyalocatedintothreegroups,namelyDES(di-ethylstilbestrol)group,DES+TAMgroupandblankcontrolgroup.WefoundthatinDES+TAMgroupthelevelsofestradiol(62.14pg/ml)andprogesteron(15.02ng/ml)inserumwereobviouslyhigherthanthoseinDESgroup(52.69pg/ml,10.38ng/ml)individualy(P<0.05,P<0.01),theinci-dence(28.57%)ofmammaryhyperplasiawassignificantlylowerthanthatinDESgroup(73.33%)(P<0.025),thedegreeofhyperplasiamarkedlyslighterthanthatinDESgroup(P<0.025),andtheAg-NORcount(1.93%),DNAcontent(80.24%)andERpositiverate(36.46%)wereobviouslylowerthanthoseinDESgroup(2.43%,95.60%,71.71%)individualy.TheresultsindicatedthatTAMcouldincreasethelevelsofestradiolandprogesteroneinserum,alsocoulddecreasetheERcontents,AgNORcountsandDNAcontentsinmammaryepithelium.ItsuggestedthattheTAMcouldinterferetheeffectonthebreastcarcinogenesisinducedbyexogenousestrogen.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1996年第3期176-179,共4页
Chinese Journal of Surgery
