摘要
目的：探讨内皮素－１（ＥＴ－１）和过氧化脂质（ＬＰＯ）在妊高征发病中的作用。方法：分别用放射免疫法、硫代巴比妥酸荧光微量法和邻苯二酚自氧化法，测定９５例妇女血浆ＥＴ－１、ＬＰＯ和红细胞超氧化物歧化酶（ＲＢＣ－ＳＯＤ）的活性。其中正常非妊娠妇女１５例（对照组），正常晚期妊娠妇女２０例（正常妊娠组），妊高征患者６０例（妊高征组）。结果：（１）正常妊娠组血浆ＥＴ－１、ＬＰＯ和ＲＢＣ－ＳＯＤ活性均高于对照组（Ｐ＜０．０１），但ＬＰＯ／ＲＢＣ－ＳＯＤ比值差异无显著性；（２）妊高征组的ＥＴ－１和ＬＰＯ／ＲＢＣ－ＳＯＤ比值显著高于正常妊娠组，且随病情的加重而升高，产后３～７天迅速下降；（３）妊高征组的ＥＴ－１和ＬＰＯ／ＲＢＣ－ＳＯＤ比值呈正相关（ｒ＝０．８４６，Ｐ＜０．００１）。结论：提示机体内氧化和抗氧化平衡失调与内皮细胞损伤，在妊高征发病过程中起重要作用。
Objective:Toevaluatetheroleofendothelin(ET-1)andlipidperoxidate(LPO)inthepathogenesisofpregnancy-inducedhypertension(PIH).Methods:TheplasmaconcentrationsofET-1,LPOandtheamountofsuperoxidatedismutase(SOD)inredbloodcelweremeasuredbyradioimmunoassay,thiobarbituricacidfluorimetricdeterminationandcatecholself-oxidationdeterminationrespectivelyintotal95women(normalnon-pregnantwomen15,Latepregnantwomen20andpatientswithPIH60).Results:(1)ThelevelsofET-1,LPOandSODinnormallatepregnantwomenweresignificantlyhigherthanthoseinnon-pregnantwomen(P<0.01),buttheLPO/SODratiowasnotsignificantlydiferentbetweenthetwogroups.(2)ThelevelsofplasmaET-1andLPO/SODratioincaseswithPIHweremarkedlyhigherthanthoseinnormallatepregnantwomen,anditincreasedwiththeseverityofthediseaseandreturnedtothelevelsofnormallatepregnantwomenwithin3～7daysafterdelivery.(3)TherewasapositivecorrelationbetweenET-1andLPO/SODratioinPIH.Conclusions:TheimbalanceofoxidationandantioxidationandendothelialcelinjurymayplayanimportantroleinthepathogenesisofPIH.
出处
《中华妇产科杂志》
CSCD
北大核心
1996年第4期220-222,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠高血压
综合征
血浆
内皮素
LP
SOD
Pregnancycomplications
cardiovascularHypertensionEndothelinsLipidperoxidesSuperoxidedismutase
