摘要
目的:探讨中药中风康对局灶性脑缺血大鼠脑组织超微结构的影响。方法:采用线栓法复制局灶性脑缺血大鼠模型。以步长脑心通为对照,于脑缺血48 h观察中风康(主要成分:枸杞子、怀牛膝、川芎、水蛭、地龙、橘络、胆南星、石菖蒲、冰片等)对局灶性脑缺血大鼠脑组织含水量和超微结构的影响。结果:与假手术组比较,模型组出现明显的血脑屏障和神经元超微结构损害,脑组织含水量增加(P<0.01);与模型组比较,各治疗组脑组织超微结构损害均有不同程度减轻,脑组织含水量均下降(P均<0.01)。结论:中风康可减轻缺血时脑组织超微结构的损害,维护血脑屏障的完整性,有效减轻脑水肿和神经元的缺血坏死。
Objective： To observe the effect of Zhongfengkang （中风康） on brain ultrastructure of rats with focal cerebral ischemia. Methods： The model of focal cerebral ischemia was replicated by inserting nylon thread. Compared with the treatment of Buchang Naoxintong （步长脑心通）, the effect of Zhongfengkang （ingredients： fructus lycii （枸杞子）, Henan achyranthes root （怀牛膝）, ligusticum （川芎）, hirudo （水蛭）, lumbricus（地龙）, tangerine pith （橘络）, arisaema cure bile （胆南星）, acorus tatarinowii （石菖蒲）, borneolum syntheticum （冰片）, etc. ） on cerebral ultrastructure and brain edema of rats with focal cerebral ischemia was observed in 48 hours after cerebral ischemia. Results： The injury of ultrastructure of blood brain barrier and neuron and the brain edema were more severe in the model group than that in the sham -operated group （P〈0.01）. While the injury of blood brain barrier and brain edema of each treatment group were milder than that of the model group （all P〈0.01）. Conclusion： Zhongfengkang can protect blood brain barrier, reduce damage of cerebral ischemia and brain edema effectively by reducing ultrastructure damage of blood brain barrier.
出处
《中国中西医结合急救杂志》
CAS
2005年第5期300-302,F0002,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
河北省中医药管理局科研计划项目(05036)
关键词
中风康
脑缺血
超微结构
脑水肿
血-脑屏障
Zhongfengkang
cerebral ischemia
ultrastructure
brain edema
blood brain barrier
