摘要
比较了小鼠经２次腹腔注射平阳霉素后骨髓嗜多染红细胞（ＰＣＥ）和外周血ＰＣＥ及正染红细胞（ＮＣＥ）微核率的诱导情况。结果表明，外周血ＰＣＥ微核率与骨髓ＰＣＥ微核率几乎为完全正相关（ｒ＝０．９９），只是外周血ＰＣＥ微核率的峰值比骨髓ＰＣＥ微核率峰值滞后２４小时。而外周血ＮＣＥ的微核率随染毒时间的延长缓慢上升，在染毒第７天基本与骨髓及外周血ＰＣＥ微核率一致。
Pingyangmycin was administered via ID injection to mice for tow times.The frequency of micronucleus in polychromatic erythrocytes(PCE) of bone marrow and in PCE and normochromatic erythrocytes (NCE) of peripheral blood was compared .The results showed that there was a very good correlation(r=0.99) between micronucleus rate in bone marrow PCE and that in peripheral blood PCE.But the peak value in peripheral blood PCE was appared latter (for 24 hours) than that in bone marrow PCE.The results also indicated that the micronucleus rate in peripheral blood PCE was increased slowly with the prolongation the toxicant exposure time.On the seventh day of the toxicant exposure the micronucleus rate in peripheral blood NCE was consistent basically with the one in peripheral blood PCE or in bone marrow PCE.
出处
《哈尔滨医科大学学报》
CAS
1996年第3期235-237,共3页
Journal of Harbin Medical University
关键词
平阳霉素
嗜多染红细胞
微核率
抗癌药
Pingyangmycin
Polychromatic erythrocyte
Normochromatic erythrocyte
Micronucleus
