摘要
对３２例海洛因依赖者作了血清超氧化物歧化酶（ＳＯＤ）水平测定，其中３０例作了血清ＩｇＧ、ＩｇＡ、ＩｇＭ、Ｃ３、Ｃ４，Ｂｆ以及循环免疫复合物（ＣＩＣ）测定，与年龄匹配的３３例健康志愿者比较，依赖组ＩｇＡ、Ｃ３和ＳＯＤ水平均显著降低（ＩｇＡ、Ｃ３，Ｐ＜０．０１；ＳＯＤ，Ｐ＜０．００１），而ＣＩＣ则显著升高（Ｐ＜０．０１）。提示长期海洛因刺激可损伤机体的Ｉｇ和补体。
he IgG,IgA,IgM,C3,C4,Bf and circulatory immune complex (CIC) levels were measured by immunodiffuse or PEG method in sera of 30 heroin addicts, and superoxide dismutase (SOD) levels by radioimmunoassay in 32 those patients. Compared with 33 age matched volunteers, the IgA and C3 levels of the addicts were significantly decreased (1 458±694 mg/L vs 2 091±1 131 mg/L, 725.2±243.9 mg/L vs 992.9±314.4 mg/L, P <0.01, respectively), CIC significantly elevated (2.60±2.35 vs 1.33±0.59, P <0.01) and SOD levels significantly decreased (256.6±54.6 μg/L vs 440.8±205.0 μg/L, P <0.001). These results suggest that the synthesis of immunoglobulin, complement components, and SOD in those people who suffer from chronic heroin stimulating might be impaired.
出处
《贵阳医学院学报》
CAS
1996年第2期98-100,共3页
Journal of Guiyang Medical College
关键词
海洛因依赖
吸毒
免疫功能
超氧化物歧化酶
heroin dependence
immunoglobulins
complement
superoxide dismutase
