摘要
扶正化瘀方与养阴柔肝方对ＤＥＮ诱发大鼠肝癌的作用结果表明，大鼠癌前期（１４周）肝细胞增生灶明显减少。肝组织ＧＧＴ、ＧＳＴ及血清ＡＬＰ活性显著下降。动物诱癌２４周后，对照组的肝癌发生率为１００％，扶正化瘀方组与养阴柔肝方组分别为９２．９％与８５．７％。用药组的癌变程度较轻，ＡＦＰ阳性区及ＧＧＴ阳性灶均降低或减少，肝组织ＧＧＴ、ＧＳＴ与血清ＡＬＰ活性降低；其中以养阴柔肝方的作用为优。
As con1pared with non-dosed controls,the liver of the rats treated with Fuzheng Huayu recipe or Yangyin Rougan recipe was observed to display obvious de-crease in the number of hyperplastic zones in the hepatocytes during the precarcinoma period. Also,activities of GGT and GST in the liver and serum ALP were markedly reduced.In the 24th week after the rats was treated bV diethylnitrosamine(DEN) for induction of hepatocarcinoma,the incidence of hepatocarcinoma was 100%in the con-trol,while 92.9%and 85.7%,respectively,in the groups treated with the two recipes.And the lower activities of GGT and GST in the live and serum ALP were also found.Yangyin Rougan recipe appeared to be more potent than the other one in preventing thecancer,The findings from hepatocyte cycle kinetics suggested that the two Chineserecipes were able to inhibit synthesis of hepatocyte DNA,leading to interruption of thecell division and proliferation.
出处
《中国实验方剂学杂志》
CAS
1996年第3期35-40,共6页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
扶正化瘀方
养阴柔肝方
中药
方剂
肝癌
Fuzheng Huayu Recipe,Yangyin Rougan Recipe,Diethylnitrosamine(DEN),Hepatocarcinoma
