摘要
本实验对４８例石蜡包埋人肝癌和癌旁组织的Ｐ^（５３）蛋白（突变型）和ＨＢｘＡｇ进行了免疫组化（ＡＢＣ法）检测。结果显示肝癌及其癌旁组织Ｐ^（５３）蛋白（突变型）和ＨＢｘＡｇ阳性率分别为２９．２％（１４／２８）和９３．８％（４５／１８），Ｐ^（５３）蛋白（突变型）与ＨＢｘＡｇ表达不相关（Ｐ＞０．０５），提示ＨＢｘＡｇ在Ｐ^（５３）基因突变中不发挥作用。
Abstract The expression of c-myc mRVA and hepatitis B virus X gene mRNA (HBx mRNA)in hepatocellular carcinoma (HCC) and corresponding non-tumorous liver (VT) tissues from 23 patients had been studied by in situ hybridization (DNA-RNA). The result showed that 11 specimens of HCC and NT were positive for cmyc mRNA and HBx mRNA staining, 5 of HCC and NT were only c-myc mRNA positive,one of HCC and NT was only HBx mRNA positive,6 of HCC and NT were negative for c-myc mRNA and HBx mRNA. The staining of c-myc mRNA was not significantly associated with HBx mRNA in HCC and NT(P>0. 05). It is suggected that HBx mRNA may not have a direct role in the activation of c-myc oncogene.
出处
《临床肝胆病杂志》
CAS
1996年第3期131-132,共2页
Journal of Clinical Hepatology
