摘要
目的比较十二指肠溃疡患者晨服奥美拉唑,睡前加服法莫替丁和加服奥美拉唑后日间酸突破(DAB)和夜间酸突破(NAB)的情况。方法将20例十二指肠溃疡患者随机分成两组,日间服用奥美拉唑20mg后,一组睡前加服奥美拉唑20mg,一组睡前加服法莫替丁40mg,疗程1周。治疗前后行夜间胃酸pH监测。结果治疗后奥美拉唑组夜间pH<4的中位时间百分比减少62.4%,法莫替丁组减少83.95%,两组之间比较P<0.05。奥美拉唑组NAB发生率为70%,法莫替丁组NAB发生率为30%,两组之间比较P<0.001。两组日间pH<4的中位时间百分比、DAB的发生率差异无显著性(P>0.05)。结论睡前服用法莫替丁比睡前服用奥美拉唑对夜间胃酸分泌和酸突破的控制更为有效。
Objective To compare the effect of a second dose of omeprazole at bedtime with that of a dose of famotidine on residue daytime acid breakthrough（DAB） and neetumal acid breakthrough（NAB） in duodenal ulcer patients receiving omeprazole once daily. Methods 20 duodentil ulcer patients underwent 24 h intragastric pH monitoring before and after 7days of treatment with omepmzole 20 mg once daily,followed by random additional supplements of omeprazole 20 mg or famotidine 40 mg at bedtime. Results After treatment the median percentage of time with intragastric pH 〈 4 during neeturnal time reduced to 62.4% in omeprazole group and 83.95% in famotidine group （ P 〈 0. 05 ）. NAB occurrence rate was 70% in omeprazole group and 30% in famotidine group（ P 〈 0. 001 ）. The median percentage of time with intragastric pH 〈 4, DAB occurrence rate during daytime between two groups were not significantly different （ P 〉 0. 05 ）. Conclusin Bedtime famotidine is more effective than bedtime omeprazole on residual neetumal acid secretion and nocturnal acid breakthrough in patient receiving omeprazole once daily.
出处
《临床消化病杂志》
2005年第5期212-213,共2页
Chinese Journal of Clinical Gastroenterology
关键词
抑酸剂
酸突破
胃酸pH监测
Acid-inhibitor
Acid breakthrough
Intragastric pH monitoring
