Synthesis and Cytotoxicity Evaluation of Some Isoquinoline Derivatives Related to 1-Arylnaphthalene Lignans
Synthesis and Cytotoxicity Evaluation of Some Isoquinoline Derivatives Related to 1-Arylnaphthalene Lignans
摘要
Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at μmol/L scale.
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10Spectral data for compound 27: 1H NMR (400 MHz, CDCl3δ ppm): 2.71 (t, 2H, J=7.4, 7.2Hz, CH2-4), 3.77 (t, 2H, J=8.2, 6.5 Hz, CH2-3), 5.10 (s, 2H, OCH2Ph), 5.12 (s, 4H, OCH2Ph),5.99 (s, 2H, OCH2O), 6.70 (s, 1H, H-5), 6.75 (s, 1H, H-8), 6.92 (s, 2H, H-2', H-6'), 7.25-7.44(m, 15H, OCH2Ph-H×3); EIMS m/z (%): 569 [M]+ (3), 91 (100). The spectral data of other synthetic compounds were deposited to the editorial office of CCL.
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