摘要
目的探讨凋亡相关基因C-myc,bcl-2,p53与血管瘤增生、消退的关系。方法采用免疫组化SP法检测31例增生期血管瘤、35例消退期血管瘤组织中Cmyc,bcl2和P53蛋白。结果Cmyc在增生期血管瘤中的阳性率为80.65%,而在消退期血管瘤组织中均呈阳性,两组之间差异显著(P<0.01)。bcl2在增生期血管瘤中的阳性率为83.87%,明显高于消退期血管瘤45.71%(P<0.01)。P53蛋白主要定位于血管瘤中的肥大细胞。增生期血管瘤中P53着色的肥大细胞数31.18±9.08/HPF明显高于消退期血管瘤14.05±6.42/HPF(P<0.01)。结论凋亡相关基因Cmyc,bcl2,p53与小儿血管瘤增生、消退密切相关,且在血管瘤增生、消退的不同时期作用不同。
Objective To investigate the relationship of C-myc, bcl-2, p53 with proliferation,regrsstion of hemangioma. Methods We observed the C-myc,bcl-2 and p53 in the tissue of 31 proliferative hemangiomas and 35 involuting hemangiomas by immunohistochemica｜ s-p method. Results The positive rate of C-myc in proliferative hemangiomas was 80, 65% , that in involuting hemangiomas was 100%, There were significantly differences beween two groups（ P 〈 0.01 ）. The positive rate 83.87% of bcl-2 was significantly higher in proliferative hemangiomas than 45.71% in involuting hemangiomas（ P 〈 0.01 ）. The positive p53 was located in the mast cells cytoplasm. The number of mast cells stained with p53 was 31.18 ±9.08/HPF in proliferative hemangiomas,higher than 14.05 ± 6.42/HPF in involuting hemangiomas （ P 〈 0.01 ）. Conclusion C-mye, bcl-2, p53 have relationship with proliferation and regression of infancy hemangiomas, have different role in various stages of hemangiomas.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2005年第10期580-582,共3页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金项目(30170912)
陕西省自然科学基金(2001SM59)
