摘要
目的:探讨telom erase与PCNA在中晚期食管癌不同大体病理类型的表达.方法:应用免疫组织化学方法观察不同大体病理类型的中晚期食管癌共126例,其中蕈伞型30例,缩窄型28例,溃疡型32例,髓质型36例.并用SPSS10.0软件分析结果.结果:中晚食管鳞状细胞癌的telom erase,PC-NA的阳性表达率分别是:蕈伞型60.0%与83.3%;缩窄型75.0%与78.5%;溃疡型75.0%与15.6%;髓质型44.4%与77.8%.2χ检验telom erase:2χ=378.829,P<0.005.PCNA:2χ=357.656,P<0.005,各组差异显著.结论:telom erase,PC-NA在不同的中晚期食管癌的大体分型之间表达不同,同时进行telom erase与PCNA免疫组化检测对于评估食管癌的预后会更有意义.
AIM： To study the expression of telomerase and PCNA protein in four different pathological types of advanced esophageal cell cancer. METHODS： One hundred and twenty-six cases with esophageal cancer of different pathological types were included in study by immunohisto- chemistry and the results were analyzed by SPSS 10.0. RESULTS： The positive rates of telomerase expression and PCNA were 60.0% （18/30） and 83.3% （25/30） in fungating type, 75.0% （21/28） and 78.5% （22/28） in constrictive type, 75.0% （24/32） and 15.6% （5/32） in ulcerative type and 44.4% （16/36） and PCNA 77.8% （28/36） in medullary type. Chi-square test was performed （telomerase ;x^2=378. 829, P 〈0. 005 and PCNA ;x^2=357. 656, P 〈 0.005）. CONCLUSION： The expression of human telomerase and PCNA gene was different in advanced esophageal cell cancer of different pathological types. Simultaneous immunohistochemistry examination of both telomerase and PCNA is of significance for the prognosis of esophageal cancers.
出处
《第四军医大学学报》
北大核心
2005年第19期1800-1801,共2页
Journal of the Fourth Military Medical University
