摘要
目的采用聚乳酸羟基乙酸(PLGA)研制替硝唑牙周缓释凝胶。方法根据聚合物的分子量、浓度、载药量和增塑剂等因素来优选最佳配方。结果聚合物溶液中N-甲基-2-吡咯烷酮(NMP)P、EG400、PLGA(75∶25)的最佳比例为65∶5∶30,5%替硝唑与聚合物溶液均匀混合即得凝胶。凝胶必须在室温下避光保存。结论该凝胶缓释时间长达7d,用于牙周炎的治疗有效。
OBJECIVE To prepare a biodegradable and sustained release poly（lactic- co- glycolic acid） gel for tinidazole. METHODS The optimum formulation was selected with the orthogonal design. RESULTS These studies showed that the optimum formulation containing 30% PIGA （75 ： 25 ） dissolved in 65% NMP and 5% PEG 400 with 5 % tinidazole added. The gel should be avoided from the light and stored at room temperature. CONCLUSION The gel provided sustained release of tinidazole over a 7 - day period and can be significantly decreased symptoms of periodontitis.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2005年第5期419-420,共2页
West China Journal of Pharmaceutical Sciences
关键词
聚乳酸羟基乙酸
替硝唑
缓释凝胶
正文试验
Poly（lactic- co- glycolic acid）
Tinidazole
Sustained release gel
Orthogroal desigh
