摘要
在地高辛常规监测中，用血肌酐值法预测个体化药动学参数和给药方案。结果表明，８４例病人的地高辛药物动力学参数预测值为，ＣＬ７６±２１ｍｌ／（ｋｇ·ｈ），Ｖｄ７．０５±１．２０Ｌ／ｋｇ，Ｔ１／２６６±７ｈ。预测的个体化剂量为３．１±０．９μｇ／（ｋｇ·ｄ），预测的稳态血药浓度（Ｃ＿（ｓｓ））为１．２４±０．３８μｇ／Ｌ，与实测Ｃ＿（ｓｓ）１．２±０．４μｇ／Ｌ比较，差异无显著性（Ｐ＞０．０５）。
ccording to serum creatinine and creatinine clearance,individualizing pharmacokinetic parameters and dosageregimens of digoxin were predicted,during clinical routine monitoring. The results of clinical application showedthat forecasting pharmacokinetic parameters were,respectivily, CL76 ± 21ml/ (h . kg) , Vd 7. 05 ±1l. 20L/kg, T1 /2 66±7h in 84 with CHF. Predicted individual dosage was 3. 110±0.gμg/(kg .d) , steady state serum concentrations(Css ) was 1. 24 ± 0. 38μg/L,no significant difference to the Css monitored 1.2± 0. 4μg/L (P>0. 05) .
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第4期150-152,共3页
Chinese Journal of Hospital Pharmacy
