摘要
目的研究结核患者细胞因子变化规律和调控机制,以帮助临床鉴别诊断。方法对54例结核患者、18例肺癌患者和12例健康人血清、肺泡灌洗液、胸水及脑脊液等多种标本的各种细胞因子进行检测。结果结核患者血清白介素(IL)-12、IL-18等T h1细胞因子及IL-10、IL-4等T h2细胞因子水平均较高。各种细胞因子在脑脊液中含量均较低;干扰素γ(IFN-γ)在胸水渗出液中含量很高。前炎性因子IL-6、IL-8和肿瘤坏死因子-α(TNF-α)在结核患者中水平较高。IL-10与TNF-α的比值在结核和肿瘤患者之间有显著差异。结论细胞因子检测有助于结核病和肺癌患者的鉴别诊断。
Objective： To determine different cytokine levels in different samples of tuberculosis cases, Methods： Sera. pleural fluid, BALF and CSF were obtained from a total of ,54 tuberculosis cases, 18 lung cancer cases, and 12 healthy individuals. Different cytokines including Thl cytokines （IL-12, IL-18 and IFN-γ）. Th2 cytokines （IL-4 and IL-10）. pro-inflammatory cytokines （IL-6, IL-8. and TNF-α） and some cytokine receptors （IFN-γR and IL-12R） were detected. Results： IL-12,IL-18, IL-10 and IL-4 showed higher levels in tuberculosis patients. The levels of most cytokines in CSF were very low. but a high level of IFN-γ was observed in pleural fluid. The pro-inflammatory cytokines, IL-6, IL-8 and TNF-α. were detected at a higher level in tuberculosis cases. Ratio of IL-10 and TNF-α had a significant difference between tuberculosis and lung cancer cases. Conclusion： Cytokines detection can be used for a tuberculosis and lung cancer differential diagnosis.
出处
《山东医药》
CAS
北大核心
2005年第28期11-12,共2页
Shandong Medical Journal
基金
日美医学协会结核麻风委员会基金资助项目
河南省医学科技创新人才工程项目(2002112)
关键词
结核
细胞因子
前炎性因子
鉴别诊断
tuberculosis
eytokine
pro-inflammatory cytokine
differential diagnosis
